For high-speed data acquisition and real-time transmission and processing requirements of ultrasonic measurement system, a wireless USB-based ultrasonic data transmission method was presented, combining wireless communication technology with the advantages of USB interface technology. The system consists of ultrasonic signal acquisition module, data transmission module, data acquisition module and the computer. The system uses Cypress Semiconductor's PSoC CYRF69213 chip for wireless data transmission and the chip microcomputer inside as the main control unit. This chip recorded data to the computer and displayed through USB interface. The system is a single-chip USB interface design with very few external components. The system has an USB interface advantages such supporting hot-swappable, plug and play features and the realization of wireless transmission of data without the need for layout of communications cables. The transmission system has good stability, small size, low power, high-performance features, which has a good application prospects.