This paper focuses on the structural optimization of chemical sensor support for food safety detection. The mechanical characteristic of chemical sensor support is influenced greatly by its structural parameters. Aiming at improving dynamic stiffness of the support, the modal analysis is implemented with the dynamic theory and the finite element analysis. And a group of rational structure parameters are determined through the optimum calculation. The validity simulation of the optimization is verified by the analyses of the random vibration and harmonic response. The results demonstrate that the performance of the support of the chemical sensor applied for the food detection is enhanced greatly by the presented optimization method here.