The MIC behavior of the ship plate steel specimen with LaCl3-Zn epoxy coating in the sulfate-reducing bacteria (SRB) solution was investigated in this paper. The variation of corrosion potential over time of different specimens in SRB solution show that the corrosion potential of the specimen with LaCl3-Zn epoxy coating was obviously higher than the Zn-epoxy coating, suggesting that the LaCl3-Zn epoxy coating may offer better protection. The variations of lgflg |Z|=4.5 and fh with time show that the property of anti-infiltration and corrosion resistance of LaCl3-Zn coating is much better than the ones of Zn-epoxy coating. Results also show that more sulfides and corrosion products of LaCl3-Zn epoxy coating were produced which increased the shielding property of the coating. The experimental results of XRD and SEM are in good agreement with the ones of Ecorr, and EIS, etc. They all show that the LaCl3-Zn epoxy coating exhibits more favorable corrosion resistance property than the Zn-epoxy coating. It is obvious that coating the ship plate steel with LaCl3-Zn epoxy is an effective and promising method against the attack of SRB in marine environment.