Periploca sepium Bunge. was tested for salinity tolerance in pot experiments using three levels of salinity, 50, 100, and 200mmol/L.It was observed that the plant growth parameters and net photosynthetic rate (Pn), stomatal conductance (Gs) were enhanced under low salinity levels (50mm/L NaCl.),which reduced strongly with increasing salinity levels. Under 100mmol/L NaCl and 200mmol/L NaCl stress, the decline of Pn was mainly caused by non-stomatal factors.The water use efficiency (WUE), apparent light use efficiency (LUE) , apparent CO2 use efficiency (CUE) were enhanced under low salinity levels (50mm/L NaCl.), the maximum WUE was observed at 100mmol/L NaCl, the minimum WUE was observed at 200mmol/L NaCl, the LUE, CUE were reduced repectively by 52%,47% at 200mmol/L NaCl compared to control.Activities of the antioxidive enzymes superoxide dismutase (SOD), peroxidase (POD),and catalase (CAT) were enhanced by salts treatment (50mm/L NaCl.), but CAT activity decreased under 200 mmol/L NaCl salt stress. Malondialdehyde (MDA) concentration was non-significant versus the control under low salinity levels (50mm/L NaCl.),the largest concentration exposing to 200 mmol/L NaCl. These results suggest a possible use of Periploca sepium Bunge in Yellow River Delta regions,where salinity is often the common major abiotic stress for plants.