Development of Modified Viscoelastic Solution with Magnetic Nanoparticles – Potential Method for Targeted Treatment of Chondral Injuries

Rodica Marinescu; Dan Laptoiu; Iulian Antoniac; Cristian Petcu

doi:10.4028/www.scientific.net/KEM.583.145

Paper Titles

An Electrical Field Numerical Simulation of Implantable Pacing Electrodes
p.119

Comparison of Plantar Arch Index Calculated from Ink and Electronic Footprints
p.125

Energy Dispersive Techniques Using X-Ray Fluorescence with Primary X-Rays for Human Hard Tissues Analysis
p.129

Investigation of a Mechanical Valve Impairment after Eight Years of Implantation
p.137

Development of Modified Viscoelastic Solution with Magnetic Nanoparticles – Potential Method for Targeted Treatment of Chondral Injuries
p.145

Clinical, Biomechanical and Biomaterials Approach in the Case of Fracture Repair Using Different Systems Type Plate-Screw
p.150

New Devices for Optimization of Renoureteral Lithiasis Treatment Using ESWL
p.155

The Influence of Classical and Modern Manufacturing Technologies on the Properties of Metal Dental Bridges
p.163

Numerical Analyses of Stresses and Strains in Bone – Implant Assembly
p.169

HomeKey Engineering MaterialsKey Engineering Materials Vol. 583Development of Modified Viscoelastic Solution with...

Development of Modified Viscoelastic Solution with Magnetic Nanoparticles – Potential Method for Targeted Treatment of Chondral Injuries

Abstract:

Intra-articular treatments offer the advantage of achieving high active substance concentrations at the site of cartilage lesion. One problem with these drugs is that of low remanence. A method to prolong the survival time of substance inside the joint may improve the cartilage repair and patient symptoms. Targeted therapy aims to optimize the delivery of these drugs set in a solution of magnetic nanoparticles, by injection into the knee joint, in order to increase the residence time of active substances through the application of high magnetic field gradients in the joint area by using extracorporeal magnets. Synthesized magnetic nanoparticles, which were covered by layer-by-layer method in consecutive layers of protection, are stable and retain their character and magnetic-polymer composites features required to be used for their intended purpose. FTIR analysis demonstrated the presence of iron salts in the synthesized ferrofluid, and of the characteristic groups of polymer coating which demonstrated that the technique of embedding in polymer layers by layer-by-layer method is viable.