Microporous ß-Tricalcium Phosphate (TCP) - A Delivery Vehicle of Growth Factors and Drugs

Anke Bernstein; Norbert Suedkamp; Hermann O. Mayr; Steffen Kißling; Michael Seidenstuecker

doi:10.4028/www.scientific.net/KEM.587.93

Paper Titles

Phosphating of Calcium Carbonate for Obtaining Hydroxyapatite from the Ostrich Egg Shell
p.69

Charge State of Silver Halide Colloids Determines the Antibacterial Activity in Amorphous Calcium Phosphate
p.74

Nano Calcium Phosphate Powder Production through Chemical Agitation from Atlantic Deer Cowrie Shells (Cypraea cervus Linnaeus)
p.80

Synthesis of Nano Calcium Phosphate via Biomimetic Method for Bone Tissue Engineering Scaffolds and Investigation of its Phase Transformation in Simulated Body Fluid
p.86

Microporous ß-Tricalcium Phosphate (TCP) - A Delivery Vehicle of Growth Factors and Drugs
p.93

Traversing Phase Fields towards Nanosized Beta Tricalcium Phosphate
p.97

rhBMP-2 Induces Immature Muscular Tissue to Differentiate into Bone-Like Tissue In Vitro
p.103

In Situ X-Ray Diffraction Study of Phase Development during Hardening of β-Tricalcium Phosphate Bone Cements with Chitosan
p.109

Preparation and Characterization of Micro-Nanostructured Anatase Film
p.115

HomeKey Engineering MaterialsKey Engineering Materials Vol. 587Microporous ß-Tricalcium Phosphate (TCP) - A...

Microporous ß-Tricalcium Phosphate (TCP) - A Delivery Vehicle of Growth Factors and Drugs

Abstract:

In this present work we could show that a microporous β-TCP ceramic with interconnected porosity and 5 μm median pore diameter is a useful delivery vehicle for drugs and growth factors. However, it is necessary to combine the ceramics with degradable biopolymers, like hydrogels for retarded release. So the drug release could be increased by the factor 7 from 3 up to 21 days with concentrations having an antimicrobial activity. Concerning the growth factor, the release period was prolonged significantly.

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Periodical:

Key Engineering Materials (Volume 587)

Pages:

93-96

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.587.93

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Online since:

November 2013

Authors:

Anke Bernstein*, Norbert Suedkamp, Hermann O. Mayr, Steffen Kißling, Michael Seidenstuecker

Keywords:

Antibiotics, Beta Tricalcium Phosphate, BMP 2, Calcium Phosphate, Ceramic, Dip Coating, Drop Coating, Drug Release, Microporous

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References

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