A Transdermal Miniature Syringe Design Based on Port Ontology for Drug Delivery

Dong Xing Cao; Yi Tong Cao; Hui Li; Xiu Hong Wang; Li Zhu Lei

doi:10.4028/www.scientific.net/KEM.609-610.1464

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 609-610A Transdermal Miniature Syringe Design Based on...

A Transdermal Miniature Syringe Design Based on Port Ontology for Drug Delivery

Abstract:

In clinic practice, a strong appeal for painless transdermal injection is pursued, especially for patient drug delivery that cannot be administered orally. A new disposable painless syringe with MEMS technology is presented. The mode of micro needle array and a flexible PDMS container of hemisphere shape are given, and the behavior of the drug liquid flow through the needles is described based on port ontology to model miniature syringe and explains the phenomena of clog formation. The analysis and formulas have theoretically been derived, and the performances and the clog phenomena have been simulated. Therefore, micro needles inserted into the human skin can realize painless injection based on port ontology modeling.

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Periodical:

Key Engineering Materials (Volumes 609-610)

Pages:

1464-1469

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.609-610.1464

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Online since:

April 2014

Authors:

Dong Xing Cao*, Yi Tong Cao, Hui Li, Xiu Hong Wang, Li Zhu Lei

Keywords:

Drug Delivery, MEMS, Miniature Syringe, Port Ontology Modeling, Simulation

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References

[1] B. Stoeber., D. Liepmann, Arrays of Hollow out-of-Plane Microneedles for Drug Delivery, Journal of Microelectromechanical Systems, ASME/IEEE 14(3): 472-479 , (2005).

DOI: 10.1109/jmems.2005.844843

Google Scholar

[2] S. Henry, D. V. Mcallister, M. G. Allen, and M. R. Prausaitz, Microfabricated microneedles: a novel approach to transdermal drug delivery, J of Phamaceutical Sciences, vol. 87, pp.922-925, (1998).

DOI: 10.1021/js980042+

Google Scholar

[3] Dongxing Cao, Xiuhong Wang, Yang Ge and Chunxiang Cui. Integrated design modeling of miniature syringe for drug delivery, The 3rd Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, Jan. 6-9, 2008, Sanya, China.

DOI: 10.1109/nems.2008.4484435

Google Scholar

[4] N. Kumar, M.N.V. Ravikumar, A.J. Domb, Biodegradable block copolymers, Advanced Drug Delivery Reviews, 53, pp.23-44, (2001).

DOI: 10.1016/s0169-409x(01)00219-8

Google Scholar

[5] D.X. CAO, Q.L. JIA, J. YANG, C.C. CU Port-based description of functional modeling for product conceptual design, Journal of Advanced Manufacturing Systems, 2008, vol. 7(1): 101-105.

DOI: 10.1142/s0219686708001176

Google Scholar

[6] Cao Dongxing, Jia Qiuling, Wang Xiuhong, Zhang Xujing, Nan Laxiang Miniature syringe design of only once[p], Invention Patent of China, No. ZL200810152151. 3, date of authorization: 2011. 4. 20.

Google Scholar