Determination of 6 Toxic Elements in Biological Tissues by High Pressure Digestion: Inductively Coupled Plasma Mass Spectrometry

Abstract:

Objective: A method based on high pressure digestion andinductively coupled plasma mass spectrometry (ICP-MS) detection was establishedfor determination of arsenic, mercury, lead, cadmium, chromium and thallium inbiological tissues. Method: The samplesof hair, nails, viscera, blood, urine were digested with HNO₃ and H₂O₂in high pressure digestion tank ; Indium was used as internal standard element,The certified GBW07601a (CRM Human Hair) was adopted as the quality control forthe whole processes. Results: Theexcellent sensitivity and reliability were demonstrated by the method ofrecovery 82% ~ 110%, RSD (n = 5) less than 5% and the linear range of 0.020ng/mL to 100 ng/mL (r > 0.99). The prototype measurements are within thescope of the standard value. Standard addition recovery of the six elements is therange of 92% ~ 105%. Conclusion: Arapid, easy and accurate quantitative ICP-MS method was established fordetermination of toxic elements in the human body, which enrich the existing meansof forensic technology. At the same time, this work provide the most practicaland reliable core data for poisons metabolism and pathological study.

• Periodical: Key Engineering Materials (Volume 633)
• Pages: 520-523
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.633.520
• Online since: November 2014
• Authors: Yi Rui Chen, Hui Jun Zou, Run Sheng Zhang, Li Bo Zeng, Hai Yun Qu, Yu Rong Zhang, Yong Sheng Chen
• Keywords: Biological Tissue, High Pressure Digestion, ICP-MS, Toxic Elements

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