Stimuli Responsive Matrices for Medical Applications

Abstract:

Different types of stimuli responsive polymers that respond with a property change to a variation in the environmental conditions are an attractive class of materials for advanced applications in biomedical or pharmaceutical fields. Three types of responsive biocompatible and biodegradable polymer matrices are presented as potential biomaterials for medical application as carriers for various drugs and tissue engineering substitutes. Hybrid hydrogels based on collagen/ N-isopropyl acrylamide containing montmorillonite nanoparticles are promising materials for tissue engineering and also as carriers for norfloxacin, a chemotherapeutic antibacterial agent. Semi-interpenetrated hydrogels based either on substituted anhydride modified collagen and 2-hydroxyethyl methacrylate or on alginate and poly (N-isopropylacrylamide) were tested as matrices for the controlled delivery of bisoprolol fumarate, an antihypertensive drug and respectively of ketoprofen, a non-steroidal anti-inflammatory drug.

• Periodical: Key Engineering Materials (Volume 638)
• Pages: 249-254
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.638.249
• Online since: March 2015
• Authors: Raluca Petronela Dumitriu*, Daniela Pamfil, Manuela Tatiana Nistor, Cornelia Vasile
• Keywords: Alginate, Collagen, Drug Delivery, Poly(N-isopropylacrylamide), Stimuli Responsive

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