Study of Adsorption Doxorubicin by Iron-Carbon Composite Powders

Abstract:

Method of electric-spark dispersion of iron particles in water, ethyl alcohol, phosphoric acid solution and hexane has been applied to produce composite magnetic nanosized powders. Their phase composition, dispersity, magnetic susceptibility, and adsorption-desorption properties towards anti-tumor remedy doxorubicin have been studied. It is shown that the obtained powder in hexane has the highest adsorption capacity towards doxorubicin. This is probably the evidence of surface compound formation. It is durable adsorption complex, which is formed from carbonyl and amine groups of organic cations and vacant orbitals of iron d-sublevel. The powder, obtained in hexane, can be dissolved in human blood plasma and amino acid solutions: possible time of iron elimination from human organism is smaller than 10 days. It is shown possibility of application iron-carbon sorbent is in quality of magnetic carrier doxorubicin to cancer cells.

• Periodical: Key Engineering Materials (Volume 683)
• Pages: 331-337
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.683.331
• Online since: February 2016
• Authors: Tatyana Yurmazova*, Victoria Ivanova, Mihail Buldakov, Sergey Galanov
• Keywords: Adsorption, Doxorubicin, Iron Nanoparticle, Iron-Carbon Sorbent, Pulse Electric Disch, Sorption Isotherms, Zeta-Potential

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