Bioactive Glasses in Treating Bone Infections

Abstract:

Bone infections are challenging due to their difficult and prolonged treatment, considerable possibility of relapse and strong negative physical and emotional impact. Since their treatment require thorough excisions, bone substitutes have been studied for restoring bone continuity, but with limited efficacy due to the pathophysiology of bone infections; one of the classes which proved to be efficient were the BioActive Glasses [BAG], synthetic biocompatible inorganic materials with a controlled ionic release, with demonstrated properties of wound healing, osteoconduction, angiogenesis and antibacterial activity. This paper presents the clinical experience from a Level 1 Trauma Centre where post-traumatic osteitis was treated using BioActive Glasses as bone fillers, demonstrating the potential clinical impact of these materials. The outcome of the patients was favourable, with no relapse of sepsis, therefore proving the efficacy of BAG in cases with limited grafting possibilities

• Periodical: Key Engineering Materials (Volume 758)
• Pages: 245-249
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.758.245
• Online since: November 2017
• Authors: Olivera Lupescu*, Mihail Nagea, Alexandru Dimitriu, Iulian Antoniac
• Keywords: Angiogenesis, Antibacterial Activity, Bioactive Glass, Bone Filling, Bone Infection, Osteitis, Osteoconduction

References

[1] MN Rahaman, DE Day, BS Bal, Q Fu, SB Jung, LF Bonewald, et al, Bioactive glass in tissue engineering, Acta Biomaterialia. 7( 2011) 2355–73.

DOI: 10.1016/j.actbio.2011.03.016

[2] MR Day, Bioactive glass stimulates the secretion of angiogenic growth factors and angiogenesis in vitro, Tissue Eng. 11 ( 2005) 768–77.

DOI: 10.1089/ten.2005.11.768

[3] A. Arkudas, A Balzer, G Buehrer, I Arnold, A Hoppe, R Detsch, et al, Evaluation of angiogenesis of bioactive glass in the arteriovenous loop model, Tissue Eng Part C Methods. 19 (2013) 479–86.

DOI: 10.1089/ten.tec.2012.0572

[4] D Zhang, E Munukka, L Hupa, H Ylänen, MK Viljanen, M Hupa, Factors controlling antibacterial properties of bioactive glasses, Key Engineering Materials. (2007) 173-176.

[5] R. B. Gustilo, R. M. Mendoza, and D. N. Williams, Problems in the management of type III (severe) open fractures: a new classification of type III open fractures, Journal of Trauma. 8 (1984) 742–746.

DOI: 10.1097/00005373-198408000-00009

[6] O Leppäranta, M Vaahtio, T Peltola, D Zhang, L Hupa, H Ylänen, JI Salonen, MK Viljanen, E Eerola, Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro, J Mater Sci: Mater Med. 19(2) (2008; ) 547-551.

DOI: 10.1007/s10856-007-3018-5

[7] S Begum, WE Johnson, T Worthington, RA Martin, The influence of pH and fluid dynamics on the antibacterial efficacy of 45S5 Bioglass, Biomed. Mater. 11 015006 https: /doi. org/10. 1088/1748-6041/11/1/015006.

DOI: 10.1088/1748-6041/11/1/015006

[8] http: /www. bonalive. com/media/uploads/documents/ortho-clinical-cases-brochure_91316f_4_ 27. 1. 2015_print_extract.

[9] VV Välimäki, HT Aro, Molecular basis for action of bioactive glasses as bone graft substitute, Scandinavian Journal of Surgery. 95(2) (2006) 95-102.

DOI: 10.1177/145749690609500204

[10] C Loty, JM Sautier, MT Tan, M Oboeuf, E Jallot, H Boulekbache, D Greenspan, N Forest, Bioactive glass stimulates in vitro osteoblast differentiation and creates a favorable template for bone tissue formation, J Bone Miner Res. 16 (2001) 231–239.

DOI: 10.1359/jbmr.2001.16.2.231

[11] M Bosetti, M Cannas, The effect of bioactive glasses on bone marrow stromal cells differentiation, Biomaterials. 26 (2005) 3873–3879.

DOI: 10.1016/j.biomaterials.2004.09.059

[12] ID Xynos, AJ Edgar, LD Buttery, LL Hench, JM Polak, Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis, Biochem Biophys Res Commun. 276 (2000).

DOI: 10.1006/bbrc.2000.3503

[13] L Drago, E De Vecchi, M Bortolin, M Toscano, R Mattina, CL Romanò, Antimicrobial activity and resistance selection of different bioglass S53P4 formulations against multidrug resistant strains, Future Microbiol. 10 (8) (2015) 1293-9.

DOI: 10.2217/fmb.15.57

[14] E Munukka, O Leppäranta, M Korkeamäki, M Vaahtio, T Peltola, D Zhang, L Hupa, H Ylänen, JI Salonen, MK Viljanen, E Eerola, Bactericidal effects of bioactive glasses on clinically important aerobic bacteria, J Mater Sci: Mater Med. 19 (1) (2008).

DOI: 10.1007/s10856-007-3143-1

[15] CL Romanò, N Logoluso, E Meani, D Romanò, E De Vecchi, C Vassena, L Drago, A comparative study of the use of bioactive glass S53P4 and antibiotic-loaded calcium-based bone substitutes in the treatment of chronic osteomyelitis - a retrospective comparative study, Bone Joint J. 96-B (2014).

DOI: 10.1302/0301-620x.96b6.33014