Controlled Drug Release Property of Nano-Porous Silica Micro Particles and their Cytocompatibility

Abstract:

In this study, we investigated in cytocompativility and controlled release behavior of a model drug from nanoporous silica microparticles (NPSM). When Mouse osteoblastic cells (MC3T3-E1) were exposed to NPMSs, they indicated excellent cell viability. From NPSM contained in dental glass ionomer cement (NPMS-GIC), they can release cationic model drug molecules gradually in water for 2 weeks when they were contained in GIC. In contrast, GIC without NPSM specimens released the molecule only a couple of days. In the case of inionic molecules, their release were alos determined only a couple of days. These results suggest that NPSM can be used as a sustainable drug-release system in dental and medical fields

• Periodical: Key Engineering Materials (Volume 782)
• Pages: 262-267
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.782.262
• Online since: October 2018
• Authors: Yuko Era, Eri Seitoku, Ko Nakanishi, Yosuke Bando, Koichi Nakamura, Shigeaki Abe*, Teruo Kusaka, Mariko Nakamura, Satoshi Inoue, Hidehiko Sano, Yasuhiro Yoshida
• Keywords: Controlled Drug-Release, Dental Glass Ionomer Cement, Nanoporous Silica Microparticle

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