Preparation, Characterization and Hemostatic Properties of Chitosan Caffeates

Abstract:

In this paper, chitosan and caffeic acid were used as starting materials to prepare chitosan caffeates by reflux-heating and freeze-drying. The structures of chitosan caffeates were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and potentiometric titration. At the same time, the physical properties of chitosan caffeates were tested and the hemostatic properties were evaluated. The results showed that four chitosan caffeates with different mass ratios of chitosan and caffeic acid (1:1, 1:2, 1:4, 1:6) had been successfully prepared, which enhanced the water solubility. FTIR analysis demonstrated that caffeic acid had been successfully grafted onto chitosan chains. XRD showed that the crystal form of chitosan changed to some extent and the chain had some regularity in some directions, but its crystallinity reduced. Chitosan caffeates, particularly mass ratio of 1:1, showed excellent hemostatic properties and even better than chitosan and the positive control (Yunnan Baiyao), which were expected to be developed as an effective biomaterial for hemostasis.

• Periodical: Key Engineering Materials (Volume 814)
• Pages: 365-371
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.814.365
• Online since: July 2019
• Authors: Si Tong Lu, Dong Ying Zhang, Zhang Hu*, Si Dong Li, Pu Wang Li
• Keywords: Caffeic Acid, Chitosan, Chitosan Caffeate, Hemostasis

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