Effect of Silica Nanoparticles on Wear Mechanism of Alginate-Polyacrylamide Hydrogel Matrix as a Load-Bearing Biomaterial

Article Preview

Abstract:

Hydrogels’ promising biocompatibility and biomimetic lubrication mechanism have led to widespread biomedical applications. To be eligible for load-bearing applications, such as cartilage reconstruction, they must be highly wear-resistant and induce ultra-low friction, once being implanted in vivo. In this study, Scanning Electron Microscopy was utilized on the worn surface of silica-nanoparticle reinforced Alginate-Polyacrylamide nanocomposite hydrogels (NCHs), as well as unmodified hydrogel as control samples, as a means of wear mechanism investigation, which is quite under-explored for these materials. Our results showed adhesion was the most prevalent wear mechanism in both NCHs and unmodified hydrogel matrix, while fatigue wear was observed in the form of surface pitting under highest load and highest test period conditions. Nevertheless, Si-NP was found to improve the wear-resistance of hydrogel matrix, as less severe surface deformation and pitting was inspected on the surface of NCHs.

You might also be interested in these eBooks

Info:

Periodical:

Pages:

15-20

Citation:

Online since:

September 2019

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2019 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

[1] N.A. Peppas, J.Z. Hilt, A. Khademhosseini and R. Langer: Adv. Mater. Vol. 18 (2006), p.1345.

Google Scholar

[2] B.V. Slaughter, S.S. Khurshid, O.Z. Fisher, A. Khademhosseini and N.A. Peppas: Adv. Mater. Vol. 21 (2009), p.3307.

Google Scholar

[3] T.R. Hoare and D.S. Kohane: Polymer Vol. 49 (2008), p. (1993).

Google Scholar

[4] M.P. Lutolf: Nature Mater. Vol. 8 (2009), p.451.

Google Scholar

[5] I. Yannas, E. Lee, D.P. Orgill, E. Skrabut and G.F. Murphy: Proc. Natl. Acad. Sci. Vol. 86 (1989), p.933.

Google Scholar

[6] J.L. Drury and D.J. Mooney: Biomaterials Vol. 24 (2003), p.4337.

Google Scholar

[7] H.-F. Ko, C. Sfeir and P.N. Kumta: Philos. Trans. R. Soc. Lond. A: Math. Phys. Eng. Sci. Vol. 368 (2010), p. (1981).

Google Scholar

[8] D. Dowson and J. Yao: Proc. Ins. Mech. Eng. J – J. Eng. Trib. Vol. 208 (1994), p.43.

Google Scholar

[9] D.J. Waters, K. Engberg, R. Parke-Houben, C.N. Ta, A.J. Jackson, M.F. Toney and C.W. Frank: Macromolecules Vol. 44 (2011), p.5776.

DOI: 10.1021/ma200693e

Google Scholar

[10] J.-Y. Sun, X. Zhao, W.R. Illeperuma, O. Chaudhuri, K.H. Oh, D.J. Mooney, J.J. Vlassak and Z. Suo: Nature Vol. 489 (2012), p.133.

DOI: 10.1038/nature11409

Google Scholar

[11] W.R. Illeperuma, J.-Y. Sun, Z. Suo and J.J. Vlassak: Extreme Mech. Lett. Vol. 1 (2014), p.90.

Google Scholar

[12] S. Skelton, M. Bostwick, K. O'Connor, S. Konst, S. Casey and B.P. Lee: Soft Matter Vol. 9 (2013), p.3825.

Google Scholar

[13] A.K. Gaharwar, N.A. Peppas and A. Khademhosseini: Biotech. Bioeng. Vol. 111 (2014), p.441.

Google Scholar

[14] A. Hoppe, N.S. Güldal and A.R. Boccaccini: Biomaterials Vol. 32 (2011), p.2757.

Google Scholar

[15] A.K. Gaharwar, S.A. Dammu, J.M. Canter, C.-J. Wu and G. Schmidt: Biomacromolecules Vol. 12 (2011), p.1641.

Google Scholar

[16] A.K. Gaharwar, C.P. Rivera, C.-J. Wu and G. Schmidt: Acta Biomater. Vol. 7 (2011), p.4139.

Google Scholar

[17] E. Taboada, R. Solanas, E. Rodríguez, R. Weissleder and A. Roig: Adv. Func. Mater. Vol. 19 (2009), p.2319.

Google Scholar

[18] Y. Liu, H. Meng, S. Konst, R. Sarmiento, R. Rajachar and B.P. Lee: ACS App. Mater. Interfaces Vol. 6 (2014), p.16982.

Google Scholar

[19] P. Mulvaney, L. Liz-Marzan, M. Giersig and T. Ung: J. Mater. Chem. Vol. 10 (2000), p.1259.

Google Scholar

[20] V. Adibnia and R.J. Hill: Polymer Vol. 112 (2017), p.457.

Google Scholar

[21] M. Arjmandi, M. Ramezani, A. Nand and T. Neitzert: Wear Vol. 406 (2018), p.194.

Google Scholar