Investigation of PLA-PEG-45S5 Bioactive Glass Composite Enhancement on Bioactivity

Abstract:

Bioactivity is an important aspect in biomaterial science ensuring materials used are safe for clinical application. The study describes fabrication of composites containing polylactic acid (PLA) – polyethylene glycol (PEG) with incorporation of sol-gel derived 45S5 bioactive glass (BG). Thermal analysis via Differential Thermal Analysis shows a favorable point over degree of crystallization that influence cells attachment, although non-significant difference in values indicates BG has homogenously dispersed. This correlates to X-ray diffraction analysis where non-significant difference is seen in intensities of the diffraction peaks, which confirms low impact of BG brittleness properties over the fabricated composite. Composites’ pH and degradation study in Simulated Body Fluid shows a steady increment profile over time and lower degradation rate for the composite after incorporation of BG. In vitro cell proliferation study also showed that HDF cells seeded on composite film of P/BG2.5 exhibit highest cell viability with steady increment of proliferation throughout the observation period.

• Periodical: Key Engineering Materials (Volume 833)
• Pages: 214-219
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.833.214
• Online since: March 2020
• Authors: Nik Syahirah Aliaa Nik Sharifulden*, Siti Noor Fazliah Mohd Noor, Siti Fatimah Samsurrijal, Siti Nur Liyana Ramlee, Nur Syazana Azizan
• Keywords: 45S5 Bioactive Glass (BG), Bioactivity, Polyethylene Glycol (PEG), Polylactic Acid (PLA), Tissue Engineering

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