Progress in Creation of a New Constant Medium for Hyperpolarized MRI

Abstract:

The MRI (Magnetic Resonance Imaging) has been used as one of the powerful tools for medical diagnoses. Its usefulness is, however, still restricted because of the low spatial resolution and long measuring time mainly due to the low NMR (Nuclear Magnetic Resonance) signals relative to the noise levels. To overcome these restrictions, we started developing a method to remarkably enlarge the NMR signals about 10 years ago. We employ a method to hyperpolarize the nuclei, where the “hyperpolarize” means to artificially generate the nuclear polarization by many orders (10²~10⁶) of magnitude higher than the ordinary NMR signals currently in use. The hyperpolarized MRI would enable us to provide images with much higher spatial resolution and shorter measuring time than ever. Several techniques for hyperpolarization have been put into practical use; the BF (Brute Force) method, PHIP (Parahydrogen Induced Polarization) method, Laser optical pumping, DNP (Dynamic Nuclear Polarization), and so on. The experimental study on the hyperpolarization of ³He by the BF method, and that of ¹⁹F in PFC (Perfluorocarbon, known as an artificial blood) by the PHIP method has gotten started. In the former method, we use an extremely low temperature realized by the Pomeranchuk cooling in combination with ³He/⁴He dilution refrigerator and high magnetic field. In the latter method, we use the hydrogenation of the parahydrogen in the unsaturated hydrocarbon substrate at room temperature. Very recently, we started developing a novel type of the hyperpolarized MRI named HMM (Hyperpolarized Metabolic MRI) hoping for the cancer diagnosis.

• Periodical: Key Engineering Materials (Volume 843)
• Pages: 52-57
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.843.52
• Online since: May 2020
• Authors: Masayoshi Tanaka*, Seiji Makino, Hisako Fujimura, Takeshi Ohta, Masaru Yosoi, Mamoru Fujiwara, Georgio Frossati, Arlette de Waard, Gérard Rouillé, Kunihiro Ueda
• Keywords: ³He/⁴He Dilution Refrigerator, Brute Force Method, HMM, Hyperpolarized Artificial Blood, Hyperpolarized MRI, PHIP (ParaHydrogen Induced Polarization), Pomeranchuk Cooling

References

[1] A. B. de González, and S. Darby, The LANCET 363 (2004) 345.

[2] F. E. Mettler et al., Radiology, 253 (2009) 520.

[3] D. J. Brenner, and E. J. Hall, New England J. Med.357 (2007) 2277.

[4] M. Tanaka, T. Kunimatsu, M. Fujiwara, H. Kohri, T. Ohta, M. Yosoi, S. Ono, K. Fukuda, K. Takamatsu, K. Ueda, J. -P. Did´elez, G. Frossati and A. de Waard, J. Conference Series 295 (SPIN2010), 012167, (2011).

DOI: 10.1088/1742-6596/295/1/012167

[5] M. Tanaka, H. Kohri, T. Ohta, M. Yosoi, M. Fujiwara, K. Ueda, S. Imoto, K. Takamatsu, J. -P. Did´elez, G. Frossati, A. de Waard, Yu. Kiselev, S. Makino, H. Fujimura, K. Fukushima, S. Fukushima, and H. Kondoh, Physics of Particles and Nuclei, 44 959 (2013).

DOI: 10.1134/s106377961306021x

[6] T. Ohta, M. Fujiwara, K. Fukuda, H. Kohri, T. Kunimatsu, C. Morisaki, S. Ono, M. Tanaka, K. Ueda, M. Uraki, M. Utsuro, S. Y. Wang, M. Yosoi, Nucl. Instr. and Meth. A633 46 (2011).

DOI: 10.1142/9789814313933_0008

[7] Takeshi Ohta, Hideki Kohri, Masaru Yosoi, Mamoru Fujiwara, Masayoshi Tanaka, 16th Int. Workshop in Polarized Sources, Targets, and Polarimetry, POS (PSTP2015) 020 (2015) 1.

DOI: 10.22323/1.243.0020

[8] Masayoshi Tanaka, Seiji Makino, Hisako Fujimura, Takeshi Ohta, Masaru Yosoi, Mamoru Fujiwara, Yuto Kasamatsu, Kunihiro Ueda, Gérard Rouillé Giorgio Frossati, and Arlette de Waad, POS (PSTP2015) 045 (2015) 1.

DOI: 10.22323/1.243.0045

[9] Masayoshi Tanaka, J. Astrophysics and Aerospace Technology 5:2 (Suppl.) 17 (2017).

[10] Masayoshi Tanaka, Seiji Makino, Hisako Fujimura, Takeshi Ohta, Masaru Yosoi, Mamoru Fujiwara, and Kunihiro Ueda, J. Aerophysics and Aerospace Technology 5:2 (Suppl.) 41 (2017).

[11] B. Castaing, and P. Nozieeres, J. Phys. 40 257 (1979).

[12] M. Chapelier, G. Frossati, and F. B. Rasmussen, Phys. Rev. Lett. 42 (1979) 904.

[13] G. Frossati, ICM proceedings, Ｍünch (1979) 1585 (invited paper).

[14] M. Chapellier, G. Frossati, F. B. Rasmussen, Proc. XV Int. Congr. Refrigeration, Venice (1979).

[15] G. A. Vermeulen, S. A. J. Wiegers Rasmussen, C. C. Kranenburg, R. Jochemsen, and G. Frossati, Canadian J. Phys. 65 560 (1987).

[16] G. Frossati, Nucl. Instr. and Meth.,A 402 479 (1998).

[17] W. Griffioen, and G. Frossati, Rev. Sci. Instr. 56 1236 (1985).

[18] T. Theis, Power point file, University of California, Berkeley, Physics 250 04/17/(2008).

[19] R. W. Adams, J. A. Aguilar, K. D. Atkinson, M. J. Cowley, S.P. I. P. Elliott, S. B. Durckett, G. G. R. Green, I. G. Khazal, J. López-Serrano, and D. C. Williamson, Science 323 (2009) 1708.

[20] S. J. Nelson, J. Kurhanewicz, D. B. Vigneron, P. E. Z. Larson, A. L. Harzstark, M. Ferrone, M. van Criekinge, J. W. Chang, R. Bok, I. Park, G. Reed, L. Carvajal, E. J. Small, P. Munster, V. K.Weinberg, J. H. Ardenkjaer-Larsen, A. P. Chen, R. E. Hurd, Liv-Ingrid Odegarstuen, F. J. Robb, J. Tropp, and J. A. Murray, Science Translational Medicine 5 198ra (2013).

DOI: 10.1126/scitranslmed.3006070

[21] P. M. Richardson, A. J. Parrott, O. Semenova, A. Nordon, S. B. Duckett, and M. E. Halse, Analyst, 143 (2018) 3442.

DOI: 10.1039/c8an00596f

[22] Bruker Biospin Corp., J. Magnetic Resonance, 261 (2015) 87.

[23] Kungl. Vetenskps Akademien, The Swedish academy of science, 3 Oct. (2018).