Hyperthermia Effect on Phantom of Breast Carcinoma Tissue Induced by Mn₃O₄ Nanoparticles Synthesized by One-Step Spray Pyrolysis Method

Abstract:

In this work, the synthesis of manganese oxide nanoparticles was achieved by one-step spray pyrolysis method. The nanoparticles were synthesized just from MnCl₂ aqueous solution. The solution was nebulized to a Si substrate placed at 400 °C for 1, 5 10 and 20 min and transported at a 0.1 L /min rate in a Nitrogen flux. The X-ray diffraction confirms tetragonal Mn₃O₄ as the unique phase in the whole sample. The scanning electron microscopy images proved the achievement of irregular nanoparticles with an average diameter of 280 nm experimentally determined by dynamic light scattering. Energy dispersive X-ray and Raman spectroscopy confirmed that the nanoparticles were obtained with Mn₃O₄ single-phase and the employed methodology prevented any contamination. The nanoparticles proved to induce temperature enhancement on artificial breast tissue by exposition to microwave radiation by achieving an increase in temperature around 8 %.

• Periodical: Key Engineering Materials (Volume 853)
• Pages: 56-60
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.853.56
• Online since: July 2020
• Authors: Alexa Gaona-Esquivel, Diana S. Hernández-Manzo, Perla J. Sánchez-Trujillo, Oscar E. Cigarroa-Mayorga*, Miguel Meléndez-Lira
• Keywords: Artificial Breast Tissue, Increase in Temperature, Manganese Oxide Nanoparticles, Mn₃O₄ Raman Spectroscopy, Temperature Enhancement

References

[1] Aime, S., Benjamin D. Hallowell, Meheret Endeshaw, Matthew T. McKenna, Virginia Senkomago, Hilda Razzaghi, Mona Saraiya, Cancer mortality rates among US and foreign-born individuals: United States 2005–2014, Preventive Medicine, Volume 126 (2019), 105755,.

DOI: 10.1016/j.ypmed.2019.105755

[2] Phung, Dai Cao, Nguyen, Hanh Thuy, Phuong Tran, Thi Thu, Jin, Sung Giu, Yong, Chul Soon, Truong, Duy Hieu, Tran, Tuan Hiep, Kim, Jong Oh, Combined hyperthermia and chemotherapy as a synergistic anticancer treatment, Journal of Pharmaceutical Investigation, volume 49-5 (2019), 519-526,.

DOI: 10.1007/s40005-019-00431-5

[3] Yongzhao Hou, Bo Xiao, Zhiyuan Sun, Wen Yang, Songsong Wu, Shuai Qi, Guangwu Wen, Xiaoxiao Huang, High temperature anti-oxidative and tunable wave absorbing SiC/Fe3Si/CNTs composite ceramic derived from a novel polysilyacetylene, Ceramics International, Volume 45-13 (2019), 16369-16379,.

DOI: 10.1016/j.ceramint.2019.05.165

[4] Rebelo, P.M.A. Caetano, A.S. Albuquerque, L.E. Fernandez-Outon, W.A.A. Macedo, J.D. Ardisson, Structure, magnetism and magnetic induction heating of NixCo(1-x)Fe2O4 nanoparticles, Journal of Alloys and Compounds, Volume 758 (2018), 247-255,.

DOI: 10.1016/j.jallcom.2018.05.124

[5] D.K. Mondal, C. Borgohain, N. Paul, J.P. Borah, Improved heating efficiency of bifunctional MnFe2O4/ZnS nanocomposite for magnetic hyperthermia application, Physica B: Condensed Matter, Volume 567 (2019), 122-128,.

DOI: 10.1016/j.physb.2018.11.068

[6] Baronzio G, Parmar G, Ballerini M, Szasz A, Baronzio M, et al. A Brief Overview of Hyperthermia in Cancer Treatment. J Integr Oncol 3:115 (2014),.

DOI: 10.4172/2329-6771.1000115

[7] Louise M. Cannon, Andrew J. Fagan, Jacinta E. Browne, Novel Tissue Mimicking Materials for High Frequency Breast Ultrasound Phantoms, Ultrasound in Medicine & Biology, Volume 37-1 (2011), Pages 122-135,.

DOI: 10.1016/j.ultrasmedbio.2010.10.005

[8] R. Aswathy, M. Ulaganathan, P. Ragupathy, Mn3O4 nanoparticles grown on surface activated graphite paper for aqueous asymmetric supercapacitors, Journal of Alloys and Compounds, Volume 767 (2018), Pages 141-150,.

DOI: 10.1016/j.jallcom.2018.07.067