Cryophylactic Solution Based on Pectic Oligosaccharides for the Creation of New Dosage Forms

Abstract:

For the first time in a wide temperature range, the rheology of aqueous solutions of oligo-and polysaccharides obtained by the method of combined fractionation from the secondary phytomass of apple pomace and albedo pomelo has been studied. The values of the freezing point have been determined and the possibility of the practical use of oligosaccharides as components of special-purpose preparations in liquid dosage form has been shown. On the basis of oligosaccharides obtained by the method of combined fractionation from the secondary phytomass of apple pomace and albedo pomelo, cryophylactic media have been created for the first time, possessing physicochemical stability in a wide temperature range. The main rheological and temperature characteristics of the obtained compositions have been studied and the possibility of the practical use of oligosaccharides as components of medical preparations for special purposes in liquid dosage form has been shown.

• Periodical: Key Engineering Materials (Volume 899)
• Pages: 585-598
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.899.585
• Online since: September 2021
• Authors: Raisa Gorshkova*, Dara Slobodova, Stanislav Pankov, Nickolay Novoselov
• Keywords: Combined Fractionation, Cryophylactic Solution, Oligosaccharides, Pectic Substances, Rheology

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