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Large-Scale Synthesis of Glutathione-Coated and 68Ga- Labeled Gold Nanoclusters for PET/CT Imaging of Tumors

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Abstract:

Gold nanoclusters (AuNCs) have gained popular attention in recent years because of their efficient tumor accumulation through EPR effect and renal clearance. In this work, we put forward a new approach to prepare glutathione-coated, 68Ga-labeled AuNCs (68Ga-GHS@AuNCs) with ultrasmall sizes (< 2 nm) for PET/CT imaging of tumors. GHS@AuNCs has low cytotoxicity in vitro. PET/CT imaging revealed that the 68Ga-GHS@AuNCs could target tumor and be cleared by kidney efficiently. Our study demonstrates that 68Ga-GHS@AuNCs has great potential for detection of tumors.

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Advanced Materials and Engineering Materials X View Preview

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Periodical:

Key Engineering Materials (Volume 904)

Pages:

322-326

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.904.322

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Online since:

November 2021

Authors:

Ben Chao Zheng, Qing He Wu, Chun Fu Zhang*

Keywords:

Gold Nanoclusters, Large-Scale Preparation, PET/CT Imaging, Radionuclide Labeling, Tumor Diagnosis

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© 2021 Trans Tech Publications Ltd. All Rights Reserved

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References

[1] Y-H. Kim, J. Jeon, SH. Hong, W-K. Rhim, Y-S. Lee, H. Youn, et al, Small. 7, 2052-60 (2011).

Google Scholar

[2] X-D. Zhang, Z. Luo, J. Chen, X. Shen, S. Song, Y. Sun, et al, Adv. Mater. 26, 4565-8 (2014).

Google Scholar

[3] DS. Abou, JE. Pickett, DLJ. Thorek, Br. J. Radiol. 88, 20150185 (2015).

Google Scholar

[4] I. Colombo, M. Overchuk, J. Chen, RM. Reilly, G. Zheng, S. Lheureux, Methods. 130, 23-35 (2017).

Google Scholar

[5] I. Fernández-Barahona, M. Munoz Hernando, J. Pellico, J. Ruiz-Cabello, F. Herranz, Appl. Sci. 8, 1098 (2018).

Google Scholar

[6] Y. Jia, T. Sun, Y. Jiang, W. Sun, Y. Zhao, J. Xin, et al, Analyst. 143, 5145-50 (2018).

Google Scholar

[7] P. Liu, H. Jin, Z. Guo, J. Ma, J. Zhao, D. Li, et al, Int. J. Nanomed. 11, 5003-14 (2016).

Google Scholar

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