Antimicrobial and Anti-Colorectal Cancer Activities of Some Volatile Oils

Abstract:

Volatile oils are natural compounds that can be adopted in many drug and cosmetic formulations. Many volatile oils can be extracted from natural plants and they have their own special biological activities. Nine volatile oils including pine oil (P), guava leaf oil (G), lime peel oil (L), cinnamon bark oil (C), sage oil (S), tea tree oil (T) rosemary oil (R), clove oil (CL) and jasmine sambac oil (J) were in vitro tested for anti-microbial activities against various microbes and cytotoxicity properties agianst HCT116 and HT29 cell lines. From our result, for antimicrobial activities, the most effective oil against Gram positive such as Staphylococcus aureus are T, R and L. Only P showed the great inhibition on Gram negative bacteria such as Escherichia coli. C, P, L, T and R also exhibited different inhibitory effects on the pathogenic yeasts depending on the candida species. For the antitumoral activity on colorectal cancer cell lines, C showed the most cytotoxicity on both HCT116 and HT29 cells with IC50 value of 7.7 and 74.0 μg/ml, respectively. The second most cytotoxic was guava oil with the IC50 of 101.2 and 97.91 μg/ml on HCT116 and HT29, respectively. These investigated data may be useful as information for oil selection and development of pharmaceutical dosage forms using these natural volatile oils as the ingredients.

• Periodical: Key Engineering Materials (Volume 914)
• Pages: 99-104
• DOI: https://doi.org/10.4028/p-t7pc4j
• Online since: March 2022
• Authors: Torsak Intaraphairot*, Ei Mon Khaing
• Keywords: Antimicrobial, Antitumoral, Volatile Oil

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