Solvothermal Synthesis of YF₃:Ce³⁺ Nanophosphors for Medical Applications

Abstract:

In this paper, the time effect of hydrothermal synthesis on YF₃ morphology particles is considered. The work was carried out on X-ray-excited YF₃:Ce³⁺ phosphors. The synthesis was carried out by the hydrothermal method, since it avoids high temperatures leading to particle agglomeration. The first stage of research consisted in identifying the most favorable medium for obtaining the required phase and size - water or organic matter (ethylene glycol and ethanol). Research has shown that ethylene glycol has all the advantages: it prevents agglomeration, allows us to get the required phase. Hydrothermal synthesis of YF₃ samples to determine the optimal synthesis time was carried out according to the same scheme - in an organic medium of ethylene glycol without using stabilizers for 4, 8, 12, 16, 20 hours. Our study showed that it is possible to obtain a YF₃ sample that meets the necessary requirements (including nanoscale) within 16 hours, moreover, without the use of stabilizers. In parallel with the study of the synthesis duration, an experiment was carried out on the effect of various stabilizers on the properties of the YF₃:Ce³⁺ phosphors (5%). The synthesized nanophosphors possessed effective X-ray luminescence with a maximum in the region of 300 nm, which makes it possible to use them in the composition of preparations for PDT.

• Periodical: Materials Science Forum (Volume 1040)
• Pages: 55-60
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.1040.55
• Online since: July 2021
• Authors: Anastasiia M. Dorokhina, Vadim V. Bakhmetyev*, Maxim М. Sychov, Hiroko Kominami, Arira Fujii
• Keywords: Cerium, Photodynamic Therapy, Solvothermal Synthesis, X-Ray Luminescence, Yttrium Fluoride

References

[1] Xiaojie Wang, Tianqi Sheng, Zuoling Fu, Wenhao Li, Jung Hyun Jeong, Highly uniform YF3:Ln3+ (Ln = Ce3+, Tb3+) walnut-like microcrystals: Hydrothermal synthesis and luminescent properties, Materials Research Bulletin 48 (2013) 2143–2148.

DOI: 10.1016/j.materresbull.2013.02.029

[2] Y. Cui, X.P. Fan, Z.L. Hong, M.Q. Wang, J. Nanosci. Nanotechnol. 6 (2006) 830.

[3] S. Sekiyama, M. Umezawa, S. Kuraoka, T. Ube, M. Kamimura, K. Soga, Temperature sensing of deep abdominal region in mice by using over-1000 nm near-infrared luminescence of rare-earth-doped NaYF4 nanothermometer, Scientific Reports 8(1) (2018).

DOI: 10.1038/s41598-018-35354-y

[4] Y. Gu, Q. Ran, W. She, J. Liu, Modifying cement hydration with NS @ PCE core-shell nanoparticles, Advances in Materials Science and Engineering 2017 (2017) 3823621.

DOI: 10.1155/2017/3823621

[5] L. Sudheendra, G.K. Das, Ch. Li, D. Stark, J. Cena, S. Cherry, I.M. Kennedy, NaGdF4:Eu3+ Nanoparticles for Enhanced X‑ray Excited Optical Imaging, Chem. Mater. 26 (2014) 1881−1888.

DOI: 10.1021/cm404044n

[6] V.V. Semashko, M.S. Pudovkin, A.C. Cefalas et al., Tiny rare-earth fluoride nanoparticles activate tumour cell growth via electrical polar interactions, Nanoscale Research Letters 13(1) (2018) 370.

DOI: 10.1186/s11671-018-2775-z

[7] V.V. Bakhmetyev, A.M. Dorokhina, M.M. Sychov, Mixed fluoride based nanophosphors for photodynamic therapy of cancer, Izvestia 42 (2018).

[8] V.V. Bakhmetyev, M.M. Sychev, A.I. Orlova, E.A. Potanina, A.E. Sovestnov, Yu.V. Kulvelis, Nanoluminophores for X-ray photodynamic therapy of oncological diseases, Nanoindustriya 8 (2013) 46-50.

[9] T.S. Minakova, M.M. Sychov, V.V. Bakhmetyev, N.S. Ereminа, S.P. Bogdanov, I.A. Zyatikov, L.Yu. Minakova, The Influence of Zn3(PO4)2:Mn – Luminophores Synthesis Conditions on their Surface and Luminescent Features, Adv. Mater. Res. 872 (2014) 106–111.

DOI: 10.4028/www.scientific.net/amr.872.106

[10] V.V. Malygin, L.A. Lebedev, V.V. Bakhmetyev, M.V. Keskinova, M.M. Sychov, S.V. Mjakin, Y. Nakanishi, Synthesis and Study of Luminescent Materials on the Basis of Mixed Phosphates, Adv. Intell. Syst. Comput. 519 (2016) 47–54.

DOI: 10.1007/978-3-319-46490-9_7

[11] A.M. Korableva, M.K. Kaczmarek, R. Van Deun, Er3+- to-Yb3+ and Pr3+-to-Yb3+ energy transfer for highly efficient near-infrared cryogenic optical temperature sensing, Nanoscale 11(3) (2019) 833–837.

DOI: 10.1039/c8nr08348g

[12] L.W. Yang, Y.Y. Zhang, J.J. Li, Y.Li, J.X. Zhonga, P.K. Chu, Magnetic and upconverted luminescent properties of multifunctional lanthanide doped cubic KGdF4 nanocrystals, Nanoscale 2 (2010) 2805–2810.

DOI: 10.1039/c0nr00326c