Removal of Bilirubin by Albumin-Fixed Polysulfone Membrane

Dong Tao Ge; Wei Shi; Lei Ren; Qi Qing Zhang

doi:10.4028/www.scientific.net/MSF.510-511.682

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HomeMaterials Science ForumMaterials Science Forum Vols. 510-511Removal of Bilirubin by Albumin-Fixed Polysulfone...

Removal of Bilirubin by Albumin-Fixed Polysulfone Membrane

Abstract:

An asymmetric polysulfone membrane with reactive group of –OH was obtained by hydrolyzing the chloromethylated polysulfone membrane, and the albumin molecules were immobilized into the membrane with a crosslinking reagent of 1,4-butanediol diglycidyl ether. The albumin-fixed membrane was used to remove lipophilic toxins, bilirubin, from the bilirubin-albumin solution. The experiment results showed that the transfer rate of bilirubin was clearly enhanced after fixing albumin into the hydroxylated polysulfone membranes. The clearance of bilirubin was 49.3%. In addition, the effect of membrane thickness on the removal of bilirubin is discussed.

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Materials Science Forum (Volumes 510-511)

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682-685

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https://doi.org/10.4028/www.scientific.net/MSF.510-511.682

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Online since:

March 2006

Authors:

Dong Tao Ge, Wei Shi, Lei Ren, Qi Qing Zhang

Keywords:

Asymmetric Membrane, Bilirubin, Fixed-Site Carrier, Lipophilic Toxins

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