Removal of Bilirubin by Albumin-Fixed Polysulfone Membrane
An asymmetric polysulfone membrane with reactive group of –OH was obtained by hydrolyzing the chloromethylated polysulfone membrane, and the albumin molecules were immobilized into the membrane with a crosslinking reagent of 1,4-butanediol diglycidyl ether. The albumin-fixed membrane was used to remove lipophilic toxins, bilirubin, from the bilirubin-albumin solution. The experiment results showed that the transfer rate of bilirubin was clearly enhanced after fixing albumin into the hydroxylated polysulfone membranes. The clearance of bilirubin was 49.3%. In addition, the effect of membrane thickness on the removal of bilirubin is discussed.
Hyung Sun Kim, Yu Bao Li and Soo Wohn Lee
D. T. Ge et al., "Removal of Bilirubin by Albumin-Fixed Polysulfone Membrane", Materials Science Forum, Vols. 510-511, pp. 682-685, 2006