Removal of Bilirubin by Albumin-Fixed Polysulfone Membrane

Abstract:

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An asymmetric polysulfone membrane with reactive group of –OH was obtained by hydrolyzing the chloromethylated polysulfone membrane, and the albumin molecules were immobilized into the membrane with a crosslinking reagent of 1,4-butanediol diglycidyl ether. The albumin-fixed membrane was used to remove lipophilic toxins, bilirubin, from the bilirubin-albumin solution. The experiment results showed that the transfer rate of bilirubin was clearly enhanced after fixing albumin into the hydroxylated polysulfone membranes. The clearance of bilirubin was 49.3%. In addition, the effect of membrane thickness on the removal of bilirubin is discussed.

Info:

Periodical:

Materials Science Forum (Volumes 510-511)

Edited by:

Hyung Sun Kim, Yu Bao Li and Soo Wohn Lee

Pages:

682-685

DOI:

10.4028/www.scientific.net/MSF.510-511.682

Citation:

D. T. Ge et al., "Removal of Bilirubin by Albumin-Fixed Polysulfone Membrane", Materials Science Forum, Vols. 510-511, pp. 682-685, 2006

Online since:

March 2006

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Price:

$35.00

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