Controlled Release of Active Substance from Biodegradable Copolymer Matrix

Abstract:

The purpose of this study is to develop a new system to control effective discharge of active substances such as agricultural chemicals. To synthesize a naturally dissolvable polymer; ε-caprolactone and diglycolide were copolymerized with ethylene glycol as an initiator to produce macrodiol. As macrodiol has hydroxyl groups in both ends, they are modified with methacryloyl chloride for photochemical networking. After standard macromonomer produced by this procedure was physically mixed with methylene blue, it was networked with ultra-violet rays to be filmed. This film is naturally dissolvable and hydrolytic. As a result of hydrolytic test with a crosslinked structure of 10 % methylene blue, it decreased by 9 % for seven weeks in 37 °C phosphate buffer solution (pH = 7). Thus, we verified that active substance can be discharged from a crosslinked structure for a long time at a constant rate under room temperature.

• Periodical: Materials Science Forum (Volumes 510-511)
• Pages: 798-801
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.510-511.798
• Online since: March 2006
• Authors: Hyung Suk So, Hyun Chul Shin, Beom Suk Kim, Yeong Seok Yoo
• Keywords: Diglycolide, Drug Delivery System, Hydrolysis, ε-Caprolactone

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