The friction and wear characteristics of a cathodic arc ion-plated CrSiN coating in sliding against different counter materials have been investigated under both unlubricated and boundary-lubricated conditions. Under boundary-lubricated conditions, the CrSiN coating exhibits a friction coefficient of 0.12 to 0.20 against a SAE 52100 steel ball and of 0.04 to 0.07 against a CrN-coated steel pin, depending on wear parameters used. The effects of load, temperature and counter materials on friction and wear of the CrSiN coating were discussed. The worn surfaces and wear debris generated under different wear conditions were examined by means of scanning electron microscopy and Raman spectroscopy to identify the tribochemical reaction and phase structures generated during the wear process. Under unlubricated conditions, iron-based oxides formed in sliding against a steel ball, while some chromium oxides were identified on worn surfaces of the CrSiN coating in sliding against an alumina ball in air.