Preparation of the Nano-Hydroxyapatite/Chitosan/Konjac Glucomannan Composite as a Novel Degradable Drug Delivery System

Gang Zhou; Yu Bao Li; Soo Wohn Lee

doi:10.4028/www.scientific.net/MSF.569.357

Paper Titles

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Effect of SPS on Surface Characteristics of Gas-Atomized Mg-6wt%Al-1wt%Zn Alloy by Non-Hazardous PEO Treatment
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Dehumidification of Air by the Composite Membrane Coated with Hydrophilic Polymer on Inorganic Substrate
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Mineralogical Characterization of Villa Reyes México Kaolin for Industrial Applications
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Performance of a Two-Phase Carbon Dioxide-Filled Thermosyphon
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Refractive Index of SiO₂-B₂O₃-Al₂O₃ Glasses
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Preparation and Characterization of KGM /TiO₂ Composite Membrane
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Preparation of the Nano-Hydroxyapatite/Chitosan/Konjac Glucomannan Composite as a Novel Degradable Drug Delivery System
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Effects of Al Addition on Mechanical Properties of Plasma Spayed Al₂O₃-Al Composite Coatings
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HomeMaterials Science ForumMaterials Science Forum Vol. 569Preparation of the...

Preparation of the Nano-Hydroxyapatite/Chitosan/Konjac Glucomannan Composite as a Novel Degradable Drug Delivery System

Abstract:

Nano-hydroxyapatite (n-HA)/chitosan (CS)/konjac glucomannan (KGM) composite was prepared by integrating composition and molding. Then, X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to analyze the physical, chemical and degradable properties of the composite before and after in simulated body fluid (SBF). Moreover, study in vitro test for drug delivery revealed that the amount of released pentoxifylline (1-[5-oxohexyl]-3,7-dimethylxanthine)(PTX) reached a plateau and equaled 80% of the drug loaded in an implant. The newly develop n-HA/CS/KGM composite may serve as a good degradable biomaterial for implantable drug delivery system (IDDS) in bone tissue engineering.