Titanium is one of structural materials. It has several advantages such as high corrosion resistance and high strength-to-weight ratio. The demand of titanium structural panel and the dissimilar joint has been increased in industry. It is well known that joining of steel and titanium is difficult because of generating the brittle intermetallic compound. In the present work, the laser roll welding of dissimilar metals, titanium to low carbon steel been investigated using a 2.4kW CO2 laser and a 2kW fiber laser. The effects of process parameters on the formation of intermetallic compound at the interlayer and on the mechanical properties were investigated to get a sound dissimilar metal joint. As a result, welded joints of titanium to low carbon steel were broken in the base metal of low carbon steel in the tensile-shear test.