Tri-Block Copolymers Obtained by RAFT Polymerization: A Promising Material for Drug-Delivery Systems

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Tri-block copolymer with pH- and thermo-responsive consisting of poly(t-butylacrylate) and poly(vinylcaprolactam), (PtBA/PVCL) were prepared by RAFT polymerization and characterized by gel permeation chromatography (GPC) and 1H NMR. PtBA and PVCL were used as macro chain-transfer agents (MCTA) to synthesize PtBA-b-PVCL-b-PtBA and/or PVCL-b-PtBA-b-PVCL, which after partial hydrolysis led to amphiphilic tri-block copolymers P(tBA-co-AA)-b-PVCL-b-P(tBA-co-AA) and/or PVCL-b-P(tBA-co-AA)-b-PVCL.

Info:

Periodical:

Materials Science Forum (Volumes 636-637)

Edited by:

Luís Guerra ROSA and Fernanda MARGARIDO

Pages:

76-81

DOI:

10.4028/www.scientific.net/MSF.636-637.76

Citation:

M.L.D.S. Tebaldi et al., "Tri-Block Copolymers Obtained by RAFT Polymerization: A Promising Material for Drug-Delivery Systems", Materials Science Forum, Vols. 636-637, pp. 76-81, 2010

Online since:

January 2010

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$35.00

[1] M. Nakayama and T.J. Okano; Drug Del. Sci. Tech. Vol. 16(1), (2006), p.35.

[2] M. Hideharu, I. Hideyuki and E. Takeshi: Reactive & Functional Polymers Vol 67 (2007), p.916.

[3] V. Boyko, A. Pichb, Y. Lub, S. Richter, K.F. Arndt and H.J.P. Adlerb: Polymer Vol 44 (2003), p.7821.

[4] H. Vihola, A. Laukkanen, H. Tenhu and J. Hirvonen: J. Pharm. Sci, Vol. 97 (2008), p.4783.

[5] X. Qiu and S.A. Sukhishvili: J. Polym. Sci.: Part A: Polym. Chem. Vol. 44 (2006), pg. 183.

[6] V. Boyko, A. Pich, Y. Lu, S. Richter, K.F. Arndt and H.J. P. Adler: Polymer Vol. 44 (2003), pg. 7821.

[7] N. Häntzschel, F. Zhang, F. Eckert, A. Pich and M.A. Winnik: Langmuir Vol. 23 (2007), p.10793.

[8] A. Imaz and J. Forcada: J. Polym. Sci.: Part A: Polym. Chem. Vol. 46 (2008), p.2510.

[9] M. Prabaharan, J.J. Grailer and D.A. Steeber and S. Gong: Macromol. Biosci. Vol. 8 (2008), p.843.

[10] D. Wan, Q. Zhou, H. Pu and G. Yang: J. Polym. Sci.: Part A: Polym. Chem. Vol. 46 (2008) p.3756.

[11] R. Devasia, R. Borsali and Y. Gnanou: Abstracts of Papers, 230th ACS National Meeting, Washington, DC, US, Aug. 28-Sept. 1, (2005).

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