Tri-Block Copolymers Obtained by RAFT Polymerization: A Promising Material for Drug-Delivery Systems

M.L.D.S. Tebaldi; T.C. Chaparro; A.M. Santos

doi:10.4028/www.scientific.net/MSF.636-637.76

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Tri-Block Copolymers Obtained by RAFT Polymerization: A Promising Material for Drug-Delivery Systems

Abstract:

Tri-block copolymer with pH- and thermo-responsive consisting of poly(t-butylacrylate) and poly(vinylcaprolactam), (PtBA/PVCL) were prepared by RAFT polymerization and characterized by gel permeation chromatography (GPC) and 1H NMR. PtBA and PVCL were used as macro chain-transfer agents (MCTA) to synthesize PtBA-b-PVCL-b-PtBA and/or PVCL-b-PtBA-b-PVCL, which after partial hydrolysis led to amphiphilic tri-block copolymers P(tBA-co-AA)-b-PVCL-b-P(tBA-co-AA) and/or PVCL-b-P(tBA-co-AA)-b-PVCL.

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Materials Science Forum (Volumes 636-637)

Pages:

76-81

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.636-637.76

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Online since:

January 2010

Authors:

M.L.D.S. Tebaldi, T.C. Chaparro, A.M. Santos

Keywords:

Poly(Acrylic Acid), Poly(t-butyl acrylate), Poly(vinylcaprolactam), RAFT Polymerization, Tri-Block Copolymer

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