An investigation has been made into the microstructure and creep behaviors of  oriented single crystal nickel-base superalloy. Results show that, after a full heat treated, the cubic phase is coherently embedded in the matrix and regularly arranged along the <100> orientation. During creep, the cubic phase in the alloy is transformed into the rafted structure lying 45 relative to the direction of the applied stress. Under the condition of the applied stress of 137 MPa at 1040°C, the alloy displays a higher strain rate and shorter creep lifetime. The deformation mode of the alloy during creep is dislocations activated within the matrix channels and the rafted phase. Dislocation slip activated easily on the Roof-type channel is thought to be the main reason of the alloy having higher strain rate and shorter creep lifetime.