Analysis of the Polymer Coatings of Coronary Stents from the Aspect of Drug Absorbing and Eluting

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Abstract:

The rate of restenosis can be decreased by the usage of drug eluting stents compared to bare metal stents. The aim of this work was the optimization of micro sprayed polymer coatings for medical applications and the examination of drug absorbing and releasing properties of these coatings. Control groups were bare metal stent models (316 LVM type austenitic stainless steel tube slices). Different types of medical grade polyurethane granules were applied onto the stent surface. Various methods were used for the examination of the surface and coating quality, such as optical microscopy, scanning electron microscopy and atomic force microscopy.

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245-250

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September 2010

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© 2010 Trans Tech Publications Ltd. All Rights Reserved

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[1] C. J. White: Drug-Eluting Stents, Advanced Applications for the management of Coronary Disease. Taylor & Francis, (2005).

Google Scholar

[2] Fülöp G., Berta B., Merkely B.: A gyógyszerkibocsátó stentekkel kapcsolatos legújabb információk. LAM 2008: 18 (1), 39-42.

Google Scholar

[3] Dr. Keltai M.: A gyógyszerkibocsátó coronariastenetek alkalmazásának hatásai. Orvosi Hetilap 148-10 (2007) 443-450.

Google Scholar

[4] H. Wieneke et al: Stent Coating: A New Approach in Interventional Cardiology, Herz 27 (2002), 518-526.

DOI: 10.1007/s00059-002-2405-4

Google Scholar

[5] Pan, C. J., Tang, J. J. and Shao, Z. Y. et al. Improved blood compatibility of rapamycin-eluting stent by incorporating curcumin. s. l. : Colloids Surf B Biointerfaces 59 (2007), 105-111.

DOI: 10.1016/j.colsurfb.2007.04.015

Google Scholar

[6] Veres M, Tóth S, Füle M, Dobránszky J, Major L, Koós M: Raman analysis of diamond-like carbon films deposited onto corrosion resistant alloys used for coronary stent fabrication. Materials Science Forum Vols. 537-538 (2007) 277-283.

DOI: 10.4028/www.scientific.net/msf.537-538.277

Google Scholar

[7] Farkas F.: Poliuretánok. KékSzám Bt. (2004) 436-440.

Google Scholar

[8] Information on http: /www. cardiotech-inc. com/casestudy. html.

Google Scholar

[9] Y.K. Lee, J. H. Park et al: The short-term effects on restenosis and trombosis of echinomycin eluting stents topcoated with a hydrophobic heparin-containing polymer. Biomaterials 28-8 (2007) 1523-1530.

DOI: 10.1016/j.biomaterials.2006.11.020

Google Scholar