Ti-35Nb-7Zr-5Ta alloy is considered an attractive material for implants manufacture due to an excellent combination of properties, including high mechanical and corrosion resistance, beyond the lowest elastic modulus among the titanium alloys. The alloy processing by powder metallurgy (P/M) eases the obtainment of parts with near-net shape forming and low production costs. Samples were produced by mixing of initial metallic powders followed by uniaxial and cold isostatic pressing with subsequent densification by sintering between 800-1600 °C, in vacuum. The isochronal sintering demonstrated to be efficient for the study of the microstructural evolution. The samples presented high densification and adequate microstructure. The results show that a beta-homogeneous microstructure is obtained in the whole sample extension when sintered at high temperatures beyond that P/M technology allows an effective porosity control.