Sterilization of Chitosan Membranes for Use as Biomaterial

Abstract:

Sterilization is a procedure which promotes complete destruction or elimination of all forms of microorganisms. It is a fundamental stage in the processing of biomaterials, and functionality of any sterilization system must be determined by its effectiveness in exterminating microorganisms without harming or adversely affect the properties of medical devices. Some sterilization techniques can react with functional groups of the polymer leading to changes in the properties, affecting the biomaterial. This study aimed to develop chitosan membranes sterilize them by following methods: an autoclave, ethylene oxide, glutaraldehyde and ultraviolet radiation and characterized by FTIR, XRD and SEM. Based on the results of this study it can be concluded that the method of sterilization indicated for the membranes of chitosan is ethylene oxide because the other altered physicochemical properties thereof.

• Periodical: Materials Science Forum (Volume 805)
• Pages: 35-40
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.805.35
• Online since: September 2014
• Authors: Imarally V.S.R. Nascimento, Rita de Cássia A. Leal, Marcus Vinícius Lia Fook, Roberta Costa Meira
• Keywords: Biomaterial, Chitosan, Sterilization

References

[1] W.A. RUTALA: Am. Journal of Infectology Control Vol. 17 (1) (1999), p.24-A.

[2] K.C.N. CARVALHO: A Esterilização. Doutorado (Tese). Campo Grande, 2002. Universidade Federal do Mato Grosso do Sul (UFMS). (MS).

DOI: 10.5212/terraplural.v.16.2219806.023

[3] B.D. RATNER, A.S. HOFFMAN, F.J. SCHOEN and J.E. LEMONS: An Introduction to Materials in Medicine. (Academic Press 1ª Ed. San Diego, 1996).

[4] S.N. SANDERS; Esterilização de termossensíveis. (2002). Disponível em http: /www. cenat. com. br/conteudo_informes. html. Acesso em 19 de junho de (2011).

[5] J.C. AZEVEDO, A.S. CRUZ and T.J.A. PINTO: Brazilian Journal of Pharmaceutical Sciences. Vol. 42 (2) (2006).

[6] J. PARK, R.S. LAKES: Biomaterials: an Introduction. (Springer 3th Edition New York, 2007).

[7] G. BIAGINI, R.A.A. MUZZERELLI, R.E. GIARDINO and C. CASTALDINI, Biological Material for wound healing. In: BRINE, I.; CHARLES, J. Advanced in chitin and chitosan. Elsevier Science Publishers, London (1992).

DOI: 10.1007/978-94-011-5942-5_3

[8] P.R.M. DALLAN: Síntese e caracterização de membranas de quitosana para aplicação na regeneração da Pele. Doutorado (Tese). Campinas, 2005. Universidade Estadual de Campinas (UNICAMP). (SP).

DOI: 10.47749/t/unicamp.2005.359143

[9] O.B.G. ASSIS, V.L. SILVA: Polímeros: Ciência e Tecnologia Vol. 13(4) (2003), p.223.

[10] I.Y. KIMURA, V.T. FÁVERE, A.O. MARTINS, V.P. SPINELLI and A. JOSUÉ: Maringá Vol. 23 (6) (2001), p.1313.

[11] M.C. TORRES, Produção e caracterização de microesferas de quitosana natural e modificada quimicamente e o seu uso na adsorção das proteínas BSA e losozima. Doutorado (Tese). Campinas, 2006. Universidade Estadual de Campinas (UNICAMP/FEQ). (SP).

DOI: 10.47749/t/unicamp.2006.375876

[12] Z.L. KNAULL, S.M. HUDSON and A.M.K. CREBER: Journal of Applied Polymer Science -Part B: Polymer. Phisical Vol. 37 (11) (1999), p.1079.

[13] H.H.K. XU and SIMON C.G. Jr.: Biomaterials Vol. 26 (2005), p.1337.

[14] T. URAGAMI and S. TOKURA, Materials Science of Chitin and Chitosan: (Kodansha Ltd. Japan, 2006).

[15] Y. KOYAMA, A. TANIGUCHI, C.P. HUANG and D.W. BLAKENSHIP: Journal of Applied Polymer Science Vol. 31 (1986), p. (1951).

[16] M.M. BEPPU, R.S. VIEIRA, C.G. AIMOLI and C.C. SANTANA: Journal of Membrane Science Vol. 301 (2007), p.126.

[17] L. LIM, E. KHOR, O. KOO: γ- Irradiation of Chitosan. (John Wiley & Sons, Inc. 1998).

[18] S.R. VIEIRA: Remoção e recuperação de íons Hg (II) utilizando quitosana natural e reticulada. Mestrado (Dissertação). Campinas, 2004. Universidade Estadual de Campinas (UNICAMP/FEQ). (SP).

DOI: 10.47749/t/unicamp.2004.319158

[19] S. NAKATSUKA and A.L. ANDRADY: Journal of Applied Polymer Science Vol. 44 p. (1992), p.17.

[20] G.A.F. ROBERTS and K.E.; TAYLOR: Makromolecules Chemical Vol. 190 (1989), p.951.