Chiral Resolution of Ofloxacin Using Carboxylated Multi-Walled Carbon Nanotubes Mediated Thin-Layer Chromatography

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Abstract:

To resolute chiral ofloxacin, we demonstrated a new method of using carboxylated multi-walled carbon nanotubes (MWCNTs) impregnated thin-lay chromatography (TLC). The relative RF value of carboxylated MWCNTs impregnated TLC was 31.3. A general discussion that focuses on the possibility of functionalized MWCNTs in the field of chromatographic chiral resolution is presented.

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Materials Science Forum (Volumes 809-810)

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128-130

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December 2014

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© 2015 Trans Tech Publications Ltd. All Rights Reserved

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[1] Zeng S., Zhong J., Pan L., et al. High performance liquid chromatography separation and quantitation of ofloxacin enantiomers in rat microsomes[J]. Journal of Chromatography B, 1999, 728 : 151-155.

DOI: 10.1016/s0378-4347(99)00085-7

Google Scholar

[2] Nakata H, Kannan K, Jones P, et al. Determination of fluoroquinolone antibiotics in wastewater effluents by liquid chromatography mass spectrometry and fluorescence detection[J]. Chemosphere, 2005, 58: 759-766.

DOI: 10.1016/j.chemosphere.2004.08.097

Google Scholar

[3] Grellet J, Ba B, Saux M C. High performance liquid chromatographic separation of fluoroquinolone enantiomers: A review [J]. J Biochem Biophys Methods, 2002, 54: 221-233.

DOI: 10.1016/s0165-022x(02)00116-1

Google Scholar

[4] Na, N.; Cui, X.; De Beer, T.; Liu, T.; Tang, T.; Sajid, M.; Ouyang, J. (2011). The use of silica nanoparticles for gas chromatographic separation. Journal of Chromatography A, 1218, 4552-4558.

DOI: 10.1016/j.chroma.2011.05.043

Google Scholar

[5] N. Mizutani, D. H. Yang, R. Selyanchyn, S. Korposh, S. W. Lee, T. Kunitake. Remarkable enantioselectivity of molecularly imprinted TiO< sub> 2</sub> nano-thin films. Anal. Chim. Acta, 2011, 694 (1), 142-150.

DOI: 10.1016/j.aca.2011.02.042

Google Scholar

[6] Huang D.S., Huang K.L., Chen S.P., Liu S.Q., Yu J.G. Rapid Reaction-Diffusion Model for the Enantioseparation of Phenylalanine across Hollow Fiber Supported Liquid Membrane. Separation Science & Technology, 2008, 43 (2) 259-273.

DOI: 10.1080/01496390701787057

Google Scholar

[7] Huang D.S., Yu J.G., Liu W., et al. Multi-Walled Carbon Nanotubes Mediated Thin-Layer Chromatographic Enantioseparation of Ofloxacin. Current Nanoscience, 2013, 9(1), 139-140.

DOI: 10.2174/157341313805118009

Google Scholar

[8] Yu J.G., Huang D.S., Huang K.L., Hong Y. Preparation of Hydroxypropyl -β-cyclodextrin Cross-linked Multi-walled Carbon Nanotubes and Their Application in Enantioseparation of Clenbuterol. Chin. J. Chem. 2011, 29, 893-897.

DOI: 10.1002/cjoc.201190185

Google Scholar

[9] R. Sancho, C. Minguillon. The chromatographic separation of enantiomers through nanoscale design. Chem. Soc. Rev. 2009, 38(3): 797-805.

DOI: 10.1039/b718359n

Google Scholar