Hydroxyapatite-Poly(Vinyl Alcohol)-Sodium Alginate Porous Hydrogels with Poly(Vinyl Alcohol) Surface Layer Used for Articular Cartilage Repair

Abstract:

The double-layered PVA/nanohydroxyapatite (nHA)-poly (vinyl alcohol)(PVA)-sodium alginate (SA) porous composite scaffolds used as synthetic articular cartilage were prepared by the freeze-thawing method, gas foaming method and crosslink method of Ca²⁺ ion, i.e., upper PVA layer for the cartilage substitute and underlying SA30 porous hydrogels for bone bonding. The microstructure and morphology of composite hydrogels were characterized using scanning electronic microscopy (SEM).It had high porosity and uniform pores. The content of HA in SA30 matrix were tested by Energy-dispersive X-ray spectroscopy (EDS). The biological properties of the composite hydrogels had been evaluated by co-culture and MTT. All results indicate that the PVA/SA30 hydrogels has good potential for repairing or replacing articular cartilage.

• Periodical: Materials Science Forum (Volume 852)
• Pages: 1155-1161
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.852.1155
• Online since: April 2016
• Authors: Xiao Bing Luo, Ming Feng Ma, Xian Ju Zhou
• Keywords: Double-Layer Structure, Hydrogel, Hydroxyapatite, Poly(vinyl alcohol), Sodium Alginate

References

[1] H.P. Yuan, Y.B. Li, JD de Bruijn, K. de Groot and X.D. Zhang: Biomaterials, Vol. 12 (2000), p.1283.

[2] R. Detsch, H. Mayr and G. Ziegler: Acta Biomaterialia, Vol. 4 (2008), p.139.

[3] E.S. Thian, K.A. Khor, N.H. Loh and S.B. Tor: Biomaterials, Vol. 22 (2001), p.1225.

[4] M. Motskin, D.M. Wright, K. Muller, N. Kyle, T.G. Gard, A.E. Porter and et al: Biomaterials, Vol. 30 (2009) No. 19, p.3307.

DOI: 10.1016/j.biomaterials.2009.02.044

[5] Mark E. Freeman, Michael J. Furey, Brian J. Love and Jeanne M. Hamp: Wear, Vol. 241 (2000), p.129.

[6] Hatice Bodugoz-Senturk, Celia E. Macias, Jean H. Kung and Orhun K. Muratoglu: Biomaterials， Vol. 30 (2009), p.589.

DOI: 10.1016/j.biomaterials.2008.10.010

[7] Damia Mawad, Ross Odell and Laura A. Poole-Warren: International Journal of Pharmaceutics, Vol. 366 (2009), p.31.

[8] K.M. Liu, Y.B. Li,F.L. Xu, Y. Zuo, L. Zhang, H.N. Wang and et al: Materials Science and Engineering C, Vol. 29 (2009), p.261.

[9] Y.S. Pan, D.S. Xiong and R.Y. Ma: Wear, Vol. 262 (2007), p.1021.

[10] R.Y. Ma, D.S. Xiong, F. Miao, J.F. Zhang and Y. Peng: Materials Science and Engineering C, Vol. 29 (2009), p. (1979).

[11] Jong Oh Kim, Jung Kil Park, Jeong Hoon Kim, Sung Giu Jin, Chul Soon Yong, Dong Xun Li and et al: International Journal of Pharmaceutics, Vol. 359 (2008), p.79.

[12] L. Wang, R.M. Shelton, P.R. Cooper, M. Lawson, J.T. Triffitt and J.E. Barralet: Biomaterials, Vol. 24 (2003), p.3475.

DOI: 10.1016/s0142-9612(03)00167-4

[13] Simmons CA, Alsberg E, Hsiong S, Kim WJ and Mooney DJ: Bone, Vol. 35 (2004), p.562.

[14] W.H. Yang, L. Zhang, L. Wu, J.F. Li, J. Wang, H. Jiang and et al: Carbohydrate Polymers, Vol. 77 (2009), p.331.

[15] Y.B. Li, de Wijn J, Klein CPAT, Meer Svd and de Groot K: Journal of Materials Science: Materials in Medicine, Vol. 5 (1994), p.252.

[16] Rosa Ricciardi, Finizia Auriemma, Claudio De Rosa and Francü oise Laupretre: Macromolecules, Vol. 37 (2004), p. (1921).

[17] F.L. Xu, Y.B. Li and X.J. Wang: Journal of Materials Science, Vol. 39 (2004), p.5669.

[18] Y.N. Dai, P. Li, J.P. Zhang, A.Q. Wang and Q. Wei: J Biomed Mater Res B, Vol. 86B (2008), p.493.

[19] X.Z. Zhang, D.Q. Wu and C.C. Chu: J Polym Sci Part B: Polym Phys, Vol. 41 (2003), p.582.

[20] C.M. Gao, M.Z. Liu, J. Chen and X. Zhan: Polymer Degradation and Stability, Vol. 9 (2009), p.1405.

[21] H.L. Wang, Y. Zuo, L. Zhang, W.H. Yang, Q. Zou, S. Zhou and et al: Materials Research Innovations, Vol. 14 (2010) No. 5, p.375.