The Application of Supercritical CO2 Based Technology for Curcumin Particle Processing

Firman Kurniawansyah; Raffaella Mammucari; Neil R. Foster

doi:10.4028/www.scientific.net/MSF.864.81

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HomeMaterials Science ForumMaterials Science Forum Vol. 864The Application of Supercritical CO2 Based...

The Application of Supercritical CO₂ Based Technology for Curcumin Particle Processing

Abstract:

Supercritical CO₂ is commonly used in the processing of natural products due to several advantageous factors such as inexpensiveness, moderate operating parameters and simple purification step. In the processing of phyto-pharmaceuticals, CO₂ has been used mostly for extraction, purification and particle formation. This article is a review of supercritical particle formation processes applied to phenolic compounds, specifically curcumin. In summary, supercritical technologies constitute a process platform for the modification of curcumin physicochemical properties. The use of supercritical CO₂ as a solute, solvent or anti-solvent in curcumin processing enabled the production of material with particle size as small as 15 nm and improved antioxidant activity.

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Periodical:

Materials Science Forum (Volume 864)

Pages:

81-85

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.864.81

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Online since:

August 2016

Authors:

Firman Kurniawansyah*, Raffaella Mammucari, Neil R. Foster

Keywords:

CO₂, Curcumin, Particle, Processing, Supercritical

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References

[1] W. -Y. Huang, Y. -Z. Cai, Y. Zhang, Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention, Nutrition and cancer, 62 (2009) 1-20.

DOI: 10.1080/01635580903191585

Google Scholar

[2] R. Mammucari, F. Dehghani, N. Foster, Dense Gas Processing of Micron-Sized Drug Formulations Incorporating Hydroxypropylated and Methylated Beta-Cyclodextrin, Pharm Res, 23 (2006) 429-437.

DOI: 10.1007/s11095-005-9094-7

Google Scholar

[3] J. Jung, M. Perrut, Particle design using supercritical fluids: literature and patent survey, The Journal of Supercritical Fluids, 20 (2001) 179-219.

DOI: 10.1016/s0896-8446(01)00064-x

Google Scholar

[4] E.J. Beckman, Supercritical and near-critical CO2 in green chemical synthesis and processing, The Journal of Supercritical Fluids, 28 (2004) 121-191.

DOI: 10.1016/s0896-8446(03)00029-9

Google Scholar

[5] T. Noiklam, A. Sane, Formation of curcumin nanoparticles using rapid expansion subcritical solutions into liquid solvents (RESOLV), Nano-Thailand, NanoThailand, (2012).

Google Scholar

[6] M. Kakran, N.G. Sahoo, I. -L. Tan, L. Li, Preparation of nanoparticles of poorly water-soluble antioxidant curcumin by antisolvent precipitation methods, Journal of Nanoparticle Research, 14 (2012) 1-11.

DOI: 10.1007/s11051-012-0757-0

Google Scholar

[7] P.J. Ginty, M.J. Whitaker, K.M. Shakesheff, S.M. Howdle, Drug delivery goes supercritical, Materials Today, 8 (2005) 42-48.

DOI: 10.1016/s1369-7021(05)71036-1

Google Scholar

[8] Ž. Knez, T. Perko, M. Škerget, Antioxidant and antimicrobial activity of PGSS micronized curcuma powder ISSF, ISSF San Fransisco, (2012).

Google Scholar

[9] F. Zabihi, N. Xin, J. Jia, T. Chen, Y. Zhao, High Yield and High Loading Preparation of Curcumin–PLGA Nanoparticles Using a Modified Supercritical Antisolvent Technique, Industrial & Engineering Chemistry Research, 53 (2014) 6569-6574.

DOI: 10.1021/ie404215h

Google Scholar

[10] F. Kurniawansyah, H.T.T. Duong, T.D. Luu, R. Mammucari, O. Vittorio, C. Boyer, N. Foster, Inhalable curcumin formulations: Micronization and bioassay, Chemical Engineering Journal, 279 (2015) 799-808.

DOI: 10.1016/j.cej.2015.05.087

Google Scholar