Preparation of Poly Acrylic Acid Acrylamide Nanometer Material and its Drug Delivery Control Potential in Alkaline Condition

Abstract:

In order to explore a smart carrier which can control drug delivery in special pH environment, a type of nanometer material, namely, poly acrylic acid acrylamide (P(AA-AM)) was synthesized with acrylic acid and acrylamide as monomers. Its structure was determined using Fourier transform infrared spectroscopy (FTIR) and its swelling properties were tested by measuring its weight evolution. The drug delivery control potential was estimated by monitoring its swelling performances in the solutions of different pH values. The cycle characteristics were also investigated to determine its degradation properties in the environment. The results indicate that the synthesized material is sensitive to pH and is suitable for controlling drug delivery at the pH range from 10 to11 and below 7. Furthermore, this material can be automatic decomposition in the environment so that it is a degradable green material without causing burden to the environment.

• Periodical: Materials Science Forum (Volume 873)
• Pages: 84-88
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.873.84
• Online since: September 2016
• Authors: Li Juan Feng*, Jin Xiu Yuan, Hai Bo Lei, Xing Rong Zheng
• Keywords: Acrylamide, Acrylic Acid, Drug Delivery, pH Sensitivity, Swelling

References

[1] G. Jonathan, A. Karim, 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems, Int. J. Phytorem. 499 (2016) 376–394.

DOI: 10.1016/j.ijpharm.2015.12.071

[2] L. W. Xia, R. Xie, X. J. Ju, W. Wang, Q. Chen, L. Y. Chu, Nano-structured smart hydrogels with rapid response and high elasticity, Nat. Commun. 4 (2013)1–11.

DOI: 10.1038/ncomms3226

[3] H.L. Lim, Y. Hwang, M. Kara, S. Varghese, Smart hydrogels as functional biomimetic systems, Biomater. Sci. 2 (2014) 603–618.

DOI: 10.1039/c3bm60288e

[4] C.K. Michael, T.P. Jonathan, D.S. Stephanie, A.P. Nicholas, Stimulus-responsive hydrogels: Theory, modern advances, and applications, Mater Sci. Eng. R. Rep. 93 (2015) 1-49.

[5] B. Elsener, E. Zurich, in: M. Raupach, B. Elsener, R. Polder, J. Mietz (Eds. ), Corrosion of Reinforcement in Concrete: Mechanisms, Monitoring, Inhibitors and Rehabilitation Techniques, 1st ed., Woodhead Publishing Limited, Cambridge, England, 2007, p.170.

DOI: 10.1533/9781845692285

[6] Y. Yang,H. Yang, Preparation of polyacrylic acid type hydrogel and its pH sensitive behavior in alkaline solution, Chinese journal of materials research, 26(1), pp.85-90, 2012(In Chinese).

[7] H. Lei, Y. Luo, L. Feng, B. Wang, synthesis and characterization of side aminopoly siloxane modified polyurethane textile coatings, Journal of Chemical Industry and Engineering, 66(2015), 4710-4715(In Chinese).

[8] D. Li, Z. Wu,C. Liang, L. Chen, Y. Zhang, Y. Nie, Analysis of the Character of Film Decomposition of Methyl Methacrylate (MMA) Coated Urea by Infrared Spectrum, Spectroscopy and Spectral Analysis, 32(2012)635-641(In Chinese).

[9] D. Kalyanmoy, P. Amrit, A. Samee, T.A. Meyarivan, Fast and elitist multi-objective genetic algorithm: NSGA-II, IEEE Trans. Evol. Comp., 6(2002) 182-197.

DOI: 10.1109/4235.996017

[10] H. Li, Y. Wang, An interpolation based genetic algorithm for solving nonlinear bilevel programming problems. Chinese Journal of Computers, 31(2008) 910-918(In Chinese).

DOI: 10.3724/sp.j.1016.2008.00910