Nanocomposite Polymer Clay to Support the Release of Drug

Maria Jose A. Oliveira; Ademar B. Lugão; Duclerc F. Parra

doi:10.4028/www.scientific.net/MSF.899.335

Paper Titles

Rapid Solidification and Laser Cladding of Gas Atomized Ni-Nb-Sn Bulk Metallic Glass
p.311

Influence of Composite Nano-Coating of Ni-Co-SiC Obtained by Electrodeposition on the Corrosion Resistance of API 5L X80 Steel
p.317

Valuation of Mechanical Properties and Microstructural Characterization of ASTM F75 Co-Cr Alloy Obtained by Selective Laser Melting (SLM) and Casting Techniques
p.323

The Role of Sintered Al₂O₃-Nb₂O₅ Front Plate on the Ballistic Performance of Multilayered Armors
p.329

Nanocomposite Polymer Clay to Support the Release of Drug
p.335

Design and Development of Compaction Tools for Powder Metallurgy
p.341

Supercapacitor Application of Powder Prepared Using the Hydrogenation Disproportionation Desorption and Recombination (HDDR) Process in Graphene Oxide
p.347

Effect of Sn and Cu on Corrosion Resistance of LaMgAlMnCoNi Type Alloys
p.353

Secondary Hardening of an AISI M3:2 High Speed Steel Sinter 23 Hot Isostatic Pressed
p.361

HomeMaterials Science ForumMaterials Science Forum Vol. 899Nanocomposite Polymer Clay to Support the Release...

Nanocomposite Polymer Clay to Support the Release of Drug

Abstract:

It is estimated that there are about 300,00 products named biomaterials that are used in the area of Health. Although they are widely used they have yet to be optimized for therapeutic use. Hence, the objective of this work was to develop nanocomposites hydrogels with poly (vinyl alcohol) (PVAl), glucantime, chitosan and synthetic clay Laponite RD, processed by gamma irradiation. To compare the behavior of drug release two systems were compared, PVAl / chitosan / clay and PVAl / clay. The morphology of the nanocomposites hydrogel was understood by using characterization techniques: X-ray diffraction, scanning electron microscopy (SEM) and atomic force microscopy (AFM) and gel fraction. The release kinetics was analyzed at 37 °C for period of 48 hours. It was observed that the slower release of the drug occurs in the delivery system composed by PVAl / chitosan / clay with correlation of the crosslink type formed by chitosan.