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HomeMaterials Science ForumMaterials Science Forum Vol. 901Synthesis and Antibacterial Activities of...

Synthesis and Antibacterial Activities of N-Phenylpyrazolines from Veratraldehyde

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Abstract:

Some novel N-phenylpyrazolines were synthesized and investigated for their antibacterial activitiy. Chalcones 2-4 which were prepared from acetophenone and veratraldehyde derivatives were reacted with phenylhydrazine to give N-phenylpyrazolines 5-7. All of the synthesized compounds were characterized using FTIR, GC-MS, and NMR spectrometers. Further, antibacterial activity of N-phenylpyrazolines were evaluated by agar well-diffusion method against Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Escherichia coli, and Shigella flexneri. The highest activity (highest inhibition zone) of compound 5 was 2.6 mm (at 1000 ppm) against B. subtillis, compound 6 was 7.25 mm (at 1000 ppm) against S. aureus, and compound 7 was 6.75 mm (at 500 ppm) against S. aureus. The results indicated that compound 6 and 7 exhibited promising antibacterial activity.

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Symposium on Nanosciences and Chemistry

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Periodical:

Materials Science Forum (Volume 901)

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124-132

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.901.124

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Online since:

July 2017

Authors:

Artania Adnin Tri Suma, Tutik Dwi Wahyuningsih*, Deni Pranowo

Keywords:

Antibacterial, Chalcone, N-Phenylpyrazoline, Veratraldehyde

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© 2017 Trans Tech Publications Ltd. All Rights Reserved

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