The purpose of this article is to design a mechatronics system to measure fluid friction losses in a specially designed fluid friction apparatus. It measured fluid flow rates by using venturi tube and orifice plate, and velocity of fluid is calculated in terms of flow rate and pipe diameter. Friction factor (K factor) of some valves and fittings such as tee, elbow, Y Junction, gate and globe valves and friction losses in pipe was measured in this system. It is one of the best methods to measure losses in pipes and fittings experimentally. It used a computer, data acquisition cards, pressure differential transmitters, venturi tube and orifice meter to measure the flow rate, pressure drops on flow rate measurement devices and pressure drops of some valves and fittings to be measured K factors. It also measured the temperature of fluid by using J type Thermocouple. A computer program is written to calculate the Reynold number of fluid, friction factor of pipe, velocity of fluid, frictional losses of fluid, flow rate and K factor of valves and fittings. Required data was received from measured quantities. The conclusion of experiments is shown in article. Volumetric flow rate range was determined 0-1 (L/s), while the pressure drop was 0-100 kPa in experiments.