Radiation Effect on Poly(ε-Caprolactone) Nanofibrous Scaffold
Nano- to micro-structured biodegradable poly(ε-caprolactone) nanofibrous scaffolds (PCL NFSs) were prepared by an electrospinning. Electrospinning has recently emerged as a leading technique for generating the biomimetic scaffolds for tissue engineering applications. The average diameter of the electrospun PCL NFSs ranged from 0.5 to 2 ㎛ depending on the solvent/nonsolvent mixture. PCL NFSs were irradiated using γ-ray and their mechanical properties and biodegradability were measured. In vitro/vivo degradation studies of the scaffolds as a function of the radiation dose were performed. The scaffolds were degraded more slowly in vitro than in vivo.
Chang Kyu Rhee
Y. M. Lim et al., "Radiation Effect on Poly(ε-Caprolactone) Nanofibrous Scaffold", Solid State Phenomena, Vol. 119, pp. 95-98, 2007