The purpose of this article is to measure fluid pressure drops against the changing velocity on the critical points of the fluid system by using mechatronics equipments and techniques. Critical points of the fluid system to be measured pressure drops are gate valve, globe valve, flow control valve, sudden enlargement, 45 or 90 junctions etc. Pressure drops occurs mentioned areas much more than other parts of fluid system. Pressure drop is directly concerning with flow rate of fluid. It was used venture-meter and orifice-plate to measure flow rate and fluid velocity in pipe. Pressure transmitters were used to measure pressure drops on the critical points of fluid system in according to changing flow rate of fluid. Pressure transmitters produce analog signals between 4-20 mA in according to changing pressure of fluid in pipe and analog input signals are interpreted through an A/D device, and is originate from pressure sensors. All the received data from pressure transmitters are transferred to computer via A/D cards. Received data from pressure transmitters is evaluated by using developed program to measure fluid friction losses with changing pressure differences and flow rate, velocity of fluid, Reynolds number, fluid type and some values can be seen on the screen of computer in real time.