Biocompatible and Biodegradable Triblock Copolymers via ATRP

Abstract:

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Novel well-defined ABA-type triblock copolymers, (PMAIPGal-b-PLA-b-PMAIPGal), were synthesized by a three-step procedure: (a) melt polycondensation of L-lactic acid using stannous chloride (SnCl2•2H2O) as a catalyst, resulting in a hydroxyl-terminated prepolymer by alkyd condensation with 1,4-butanediol, followed by (b) esterification of the PLA hydroxyl end-groups with 2-bromoisobutyryl bromide, and (c) ATRP of 6-O-methacryloyl-1,2;3,4-di-O-isopropylidene-D-galactopyranose (MAIPGal) by the bromoisobutyryl initiating groups. The resultant copolymers were characterized by 1H NMR spectroscopy and gel permeation chromatography (GPC). The biocompatible and biodegradable copolymers have potential applications as tissue engineering biomaterials or controlled release drug delivery systems.

Info:

Periodical:

Solid State Phenomena (Volumes 181-182)

Edited by:

Yuan Ming Huang

Pages:

356-359

DOI:

10.4028/www.scientific.net/SSP.181-182.356

Citation:

X. D. Tang et al., "Biocompatible and Biodegradable Triblock Copolymers via ATRP", Solid State Phenomena, Vols. 181-182, pp. 356-359, 2012

Online since:

November 2011

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Price:

$35.00

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