Biocompatible and Biodegradable Triblock Copolymers via ATRP

Xin De Tang; Xin Wang; Yuan Yuan Dou; Mei Shan Pei

doi:10.4028/www.scientific.net/SSP.181-182.356

Paper Titles

Investigation on High Laser-Induced Damage Threshold of ZrO₂-PVP Thin Films by Hydrothermal Synthesis
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Theory of the Rectifying Performance in Molecular Device: The Role of Anchoring Groups
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Extension of the Optical Absorption of TiO₂ Nanopaticles to Visible Light Region by Doping with Cobalt
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Structure and Magnetic Properties of Co_2.73Fe_0.27O₄ Synthesized by the Heat-Decomposition Method
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Biocompatible and Biodegradable Triblock Copolymers via ATRP
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Nonlinear Infrared Transmission through and Reflection Off Antiferromagnetic Sandwich NM/AFF/NM
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Effect of Alloy Disorder Scattering on Electron Mobility Model for Strained-Si_1-xGe_x/Si (101)
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Sol-Gel Derived ZrO₂-PVP Coatings with High Laser-Induced Damage Threshold
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HomeSolid State PhenomenaSolid State Phenomena Vols. 181-182Biocompatible and Biodegradable Triblock...

Biocompatible and Biodegradable Triblock Copolymers via ATRP

Abstract:

Novel well-defined ABA-type triblock copolymers, (PMAIPGal-b-PLA-b-PMAIPGal), were synthesized by a three-step procedure: (a) melt polycondensation of L-lactic acid using stannous chloride (SnCl₂•2H₂O) as a catalyst, resulting in a hydroxyl-terminated prepolymer by alkyd condensation with 1,4-butanediol, followed by (b) esterification of the PLA hydroxyl end-groups with 2-bromoisobutyryl bromide, and (c) ATRP of 6-O-methacryloyl-1,2;3,4-di-O-isopropylidene-D-galactopyranose (MAIPGal) by the bromoisobutyryl initiating groups. The resultant copolymers were characterized by 1H NMR spectroscopy and gel permeation chromatography (GPC). The biocompatible and biodegradable copolymers have potential applications as tissue engineering biomaterials or controlled release drug delivery systems.

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Periodical:

Solid State Phenomena (Volumes 181-182)

Pages:

356-359

DOI:

https://doi.org/10.4028/www.scientific.net/SSP.181-182.356

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Online since:

November 2011

Authors:

Xin De Tang, Xin Wang, Yuan Yuan Dou, Mei Shan Pei

Keywords:

Atom Transfer Radical Polymerization (ATRP), D-Galactopyranose, Glycopolymer, L-Lactic Acid, Melt Condensation

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