The Characterization of Ketoprofen-Hydroxypropyl–β-Cyclodextrin Complex with Modified Drugs Release Properties

Monica Cretan  Stamate; Carmen Gafitanu; Ciprian Stamate; Eliza Gafitanu

doi:10.4028/www.scientific.net/SSP.188.70

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The Characterization of Ketoprofen-Hydroxypropyl–β-Cyclodextrin Complex with Modified Drugs Release Properties

Abstract:

Since, anti-inflamatory drugs have a high demand due to increased incidence of pain associated with different pathology; the objectives of this paper are the synthesis, the physicochemical characterization and analysis of the tribological properties for the ketoprofen-cyclodextrin complexes. The analysis of solubility for these complexes was carried out using MathCAD software. Tribological factors were evaluated by the wear resistance of cylindrical tablets containing ketoprofen-cyclodextrin complex, methocel and magnesium stearate. The tablets with ketoprofen-cyclodextrin complexes provide good solubility and wear resistance and these are ideal for preparation of extended release systems like implantable tablets or for orally administration tablets.

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Periodical:

Solid State Phenomena (Volume 188)

Pages:

70-75

DOI:

https://doi.org/10.4028/www.scientific.net/SSP.188.70

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Online since:

May 2012

Authors:

Monica Cretan Stamate, Carmen Gafitanu, Ciprian Stamate, Eliza Gafitanu

Keywords:

Extended Release Tablets, Ketoprofen-Cyclodextrin Complex, Solubility, Wear Resistance

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References

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