A Novel Thermosensitive Composite Fabricated with Au Nanoparticles, Poly(Lactide), and Poly(N-Isopropylacrylamide)
A novel approach to load a hydrophilic bovine serum albumin (BSA) into the drug carriers was proposed in terms of thermosensitive dual-shell structures which were fabricated with poly(N-isopropylacrylamide), poly(lactide) and Au nanoparticles. Spherically well-defined dualshell structures were constructed by a modified-double-emulsion method (MDEM). The lower critical solubility temperature of the structures was shifted to 36.4 °C which was confirmed by UVVis spectroscopy.
Witold Lojkowski and John R. Blizzard
Y. S. Jo et al., "A Novel Thermosensitive Composite Fabricated with Au Nanoparticles, Poly(Lactide), and Poly(N-Isopropylacrylamide)", Solid State Phenomena, Vols. 99-100, pp. 161-164, 2004