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Study on the preparation of repaglinide chitosan microspheres with genipin Yue Zhang1,2,3,a, Xianxian Shi1,b, Yifeng Yu1,2,3,c, Yongxing Song1,d 1 School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China 2 Hebei research center of pharmaceutical and chemical engineering, Shijiazhuang, 050018, China 3 State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, 050018, China ayuezhang@hebust.edu.cn, bshixianxian2@163.com, ckdyyf@163.com, dsunnyschen@163.com Keywords: Repaglinide, Chitosan, Genipin, Microsphere Abstract.
In this paper, the repaglinide chitosan microsphere crosslinked with genipin was prepared by emulsification-chemical crosslinking method, and chitosan is used as coating materials, genipin as a crosslinking agent, repaglinide as active agent, span-80 as emulsifier.
Many factors, such as dispersing medium dosage, temperature, reaction time and the mass ratio of materials would effect on the preparation of RCM.
Journal of Controlled Release Vol. 100(2004), p. 5 [2] F.L.
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One of raw materials that can be used as a natural preservative is watermelon rind [1].
In this study spray drying techniques are used because spray dryers can be used to dry heat-sensitive materials without damaging these materials and can overcome the instability of encapsulation results during storage [6].
Experimental Materials and Apparatus.
[6] Anthony, C.E., 2015, Assessment of some Anti-nutrient Properties of the Watermelon (Citrullus lanatus) Rind and Seed, Research Journal of Environmental Sciences, Vol.9, No.5, Page. 225-232
[12] Wrolstad, R.E, Drust,R.W., Lee,J., 2005, Tracking Color and Pigment Changes In Anthocyanin Product, Journal of Trends in Food Science Technology, Vol.16, No.9, Page. 423-428

In 2013, Martín et al using rice husk ash as raw materials to prepare nepheline glass ceramics and characterized, studies show that the nepheline glass ceramics with wide sources of raw materials [7].
The purity of raw material Tb4O7 and Yb2O3 is 99.99%, and the other raw materials was analytical pure.
Batches of about 20g materials were well mixed in covered corundum crucibles under air atmosphere, the mixed materials were heated at 1100°C for 1h in a resistance furnace with the heating rate of 2°C /min, and then the system was heated up to 1400°C for 1.5 h under stirring.
Material Science and Technology, 4(1996) 65-69 [4] Liu Xiaobo, Li Baiya, Xiao Qiuguo, Fu Yongjian.
Journal of Functional Materials, 28(1997) 526-528 [5] Chang Jiazhong, Wang Zhenling, Li Min, Shi Hengzhen.

Materials and methods Materials.
Honeycomb cinder is one kind of porous materials after coal combustion in high temperature furnace, which indicates higher specific surface area and excellent adsorption capacity.
Zheng and Zh.Zhang: Journal of Yunnan University (Natural Sciences), Vol. 20(1998), p. 589-592 (in Chinese) [2] L.P.
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Liao: Journal of Hazardous Materials, Vol. 190 (2011), p. 553-558 [11] Chinese EPA: Methods for Water and Wastewater Analysis, third ed.

Currently, geopolymer based on analogy and aluminosilicates materials is used as an alternative way the OPC as binders for concretes in building materials.
The geopolymer paste as a coating material from the processing of fly ash geopolymer paste would become a major solution to minimize deterioration by protecting the surface of materials and increased strength of materials using coating method.
The morphology of the raw materials and the final product will be analyzed using X2000 and X5000 magnification to get a clear image.
Australian Journal of Basic and Applied Sciences 7(5): 230-235 (2013)
Journal on Reviews Advanced Materials Science, 30, 90-97 (2012).

Journal of Materials Processing Technology, Vol 145, Issue 1, 1 (2004), p. 46-58 [2] S.
Journal of Material Process Technology 146:193 - 202
Journal Of Materials Processing Technology 203 (2008), p.95-101
International Journal of Quality Science 2 3 (1997), p. 167-180
Indian Journal Of Engineering And Materials Sciences 16: 2(2009), p. 116-122 [19] J.A.

Small amounts of amorphous material occur in some clay.
Methodology The clay samples were purified by removing debris and other foreign materials.
Aderemi and J.O.Oludipe: Suitability of Local Clay Materials for the Synthesis of Large Pore Zeolite Catalysts: Preliminary Studies.
Journal of Pure and Applied Science 5(2) (2001) pp 223-230 [3] R.M.
Dutta : Journals of Micro porous and Mesoporous Materials.

MD has been widely used to simulate the material behaviors in a variety of materials in nano scale movement.
It was found that the ultimate tensile strain for BCC materials is smaller than FCC materials and the ultimate tensile stress for rapid stretching is larger than slow stretching.
Also, Morse potential was concluded less suitable for analyzing the materials with BCC.
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[2] H.N.G.Wadley and X.Zhou: Progress in Materials Sciences, Vol.46 (2001), p. 329

So, the PFC3D is able to precisely simulate the combined deformation of cantilever beam, and this work has special reference to engineering calculations and designs when PFC is applied to model the mechanical behaviors of continuum materials.
It is adducible that the applications of DEM in geotechnics have become almost systematic[6], but fewer investigations are performed on the mechanical properties of continuum materials employed in civil engineering.
l PFC3D is applicable for structural computation even for continuum materials.
Cundall: International Journal of Rock Mechanics and Mining Sciences, 41(2004), p. 1329-1364
Magnier: Electronic Journal of Geotechnical Engineering, Bouquet(08), 2008, p. 1-44.

Acknowledgements This research was supported by the National Natural Science Foundation of China, under Grant No. 50775197.
JOURNAL OF MECHANICAL ENGINEERING, 2009, 48(8)：255-260
JOURNAL OF MECHANICAL ENGINEERING, 2009,45(6)：211-215
Journal of the Mechanics and Physics of Solids, 2009, 57(4)：706-727
Advances in discrete element methods for particulate materials[J].