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Polymer-tethered pH-sensitive Magnetic Nanoparticles for Targeted Delivery of Anti-cancer Drug Yueqing Shen1,a, Menglu Pu1,b, Wei Jiang1,c* 1National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology, Nanjing 210094, China ashenyueqing@126.com, b494591992@qq.com, cclimentjw@126.com Keywords: pH-sensitive;Magnetic nanoparticles;Drug delivery;Doxorubicin Abstract: Efficient delivery of drug to tumor cells is one of the crucial issues in cancer therapy.
Recently, some stimuli-sensitive materials have been reported to improve the absorption of anticancer drugs because they can make sharp respond according to the changs in microenvironment of some pathological sites, such as heat, light, or acidic conditions.4-6 Among the various stimuli, pH is the most widely used chemical stimuli because pH values vary significantly in different tissues and cellular compartments.
Futhermore, introduction of specific ligands such as folic acid (FA) can also help the magnetic nanoparticles (MNPs) deliver the dugs to the targeted cells via the receptor mediated endocytosis.7 In this work, a biocompatible and very sensitive to pH and ionic strength material, i.e., PAA, is chosen for improving the absorption of the magnetic nanoparticles-based drug.
Acknowledgements The authors are grateful for the financial support of National Natural Science Foundation of China (Nos. 50602024, 50972060), the Scientific and Technical Supporting Programs of Jiangsu province (BE2012758) and the Scientific Research Fund from NJUST Research Funding (No. 2010ZDJH06), the Fundamental Research Funds for the Central Universities (No. 30920130112003).
Wang, Novel water-soluble and pH-responsive anticancer drug nanocarriers: Doxorubicin–PAMAM dendrimer conjugates attached to superparamagnetic iron oxide nanoparticles (IONPs), Journal of Colloid and Interface Science 363 (2011) 403-409

It is necessary to strengthen the village function as the hinterland of the industrial base or park, which could provide living spaces, raw materials as well as primary products producing base.
Badaling science and educational garden in Yanqing County, as an important research base, gathers a lot of research and teaching institutions.
At the same time, the science and educational park and other cultural and educational projects produce a lot of consumer demand, which will lead to an increase of commercial and cultural and entertainment lands in surrounding areas.
Acknowledgements This work was financially supported by Program for New Century Excellent Talents in University, and The National Twelfth Five-year Science and Technology Support Program (2013BAJ12B02-1) References [1] Caroline Ashley, Brian Jones.
International Journal of Tourism Research, 2001 (3): 407-423

Double Face with Pattern Effect Design of Thermal Jacquard Based on Three-Layer Weave Structure Jin Zimin1,a, Junqing Xu1,b, Wu Jianhua2,c, Yan Yuxiu1,d 1Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, China 2Wujiang Dingsheng Silk Co.
Table 1 The specification used for fabric design parameters warp weft density 115 ends/cm 90 picks/cm material A 22.2/24.4 dtex silk×2 (beige) B 22.2/24.4 dtex silk×2 (beige) A 22.2/24.4 dtex silk×5 (fuchsia) B 22.2/24.4 dtex silk×5 (atrovirens) C 83.3 dtex far infrared polyester (white) D 125 dtex 100%wool (yellow) E 125 dtex 100%wool (mazarine) arrangement 1:1 1:1:1:1:1 machine rapier loom with 4800-needle electronic equipment weft accumulator: 5 Pattern Overlay In this paper two completely independent patterns presented in the face and back layers were added together to generate only a pattern card[3].
Acknowledgements This work was financially supported by the Suzhou science and technology bureau(SS201343) and Zhejiang leading team of science and technology innovation (2011R50004).
Zuo: Modern Silk Science and Technology Vol. 28 (2013), p.112 [3] A.D.
Zhou: Journal of Textile Research Vol. 32 (2011), p.38

Condensation of methyl propionate with formaldehyde to methyl methacrylate over Cs-Zr-Mg/SiO2 catalysts Shuang Ding1,2 , Lei Wang2 , Ruiyi Yan2, Yanyan Diao2, Zengxi Li2, Suojiang Zhang2,a and Shaojun Wang1,b 1Dalian Polytechnic University, Dalian 116034, PR China 2Beijing Key Laboratory of Ionic Liquids Clean Process, State Key Laboratory of Multiphase Complex System, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China asjzhang@home.ipe.ac.cn, bwgsoju@163.com Keywords: Condensation; Methyl methacrylate; Cesium; Magnesium; Zirconium Abstract.
Introduction Methyl methacrylate (MMA) is an important organic chemical raw material,which is widely used for producing polymethyl methacrylate or producing polymer dispersions for paints and coatings.
Although the condensation route is cleaner than the ACH process, a major drawback associated with this type of process is the low single-pass yield of MMA in the aldol condensation reaction, which results in extensive recycle of the unreacted starting materials.
Acknowledgements This work was supported by the 973 Project of China (Project No. 2009CB219900), by the National Natural Science Foundation of China (No. 21036007), and by General Program of National Natural Science Foundation of China (No. 21076221).
Iglesia: Journal of Catalysis Vol. 190 (2000), p. 261–275

Electromagnetic and thermal material properties used in the model are temperature dependent and ensure the correct behavior of the model in the whole investigated temperature range.
Common material data (relative permeability and electric resistivity) for standard aluminum have been used.
For the thermal calculations (thermal conductivity and heat capacity) basic material values of aluminum have been chosen [2].
Acknowledgements This research was partially financially supported by the Ministry of Education and Science of the Russian Federation (basic part of government contract, project No. 1436).
Rapoport, The successive parameterization method of control actions in boundary value optimal control problems for distributed parameter systems, Journal of Computer and Systems Sciences International. 48, 3 (2009) 351-362

Materials and Methods Plant Material and Cultivation.
Acknowledgment We offer our thanks to National Agricultural Science and Technology Achievements Transformation Fund (Grant Number:2012GB2A100015) and Major scientific and technological projects in Tianjin Science and Technology Commission (Grant Number: 12ZCDZNC0480) in the People's Republic of China.
White: Science,Vol. 47(2001), p. 21-28
Wilson: American Journal of Botany, Vol. 87(2000), p. 60-607

So we doped intrinsic graphene with Mn atom referring to previous research methods for DMS[11,12], by substitutional dopant to generate and modify dilute magnetic properties of graphene material.
*Project supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China (Grant No. 2011ZX02707).
Firsov: Science Vol. 306 (2004), p. 666 [4] B.
Matter Vol. 20 (2008), p. 115209 [10] Narjes Gorjizadeh and Yoshiyuki Kawazoe: Materials Transactions Vol. 49 (2008), p. 2445 [11] Y.
Jiang: New Journal of Physics Vol.12 (2010), p. 063020

Lourenço, Non-destructive tests for the structural assessment of a historical bridge over the Tua River, Key Engineering Materials 569-570 (2013) 390-397 [4] A.
Piccioni, Mechanical characterization of Apricena marble by ultrasonic immersion tests, Key Engineering Materials (2014)
The Open Construction and Building Technology Journal, 7 (2013), 43-50.
Construction and Building Materials, 21(2007), 1311–1321
Giannoccaro, Identification of the modal properties of a building of the Greek heritage , Key Engineering Materials, (2014). [ [15] S.

The earliest application of AE in concrete material was performed by Robinson [6] in 1965.
The application of AE technique for homogeneous material has matured considerably.
However, AE appearance due to the fracture within heterogeneous material was obscure.
When RC was fractured, AE events of many frequencies would perform for the cracks over different materials such as aggregate or cement mortar.
Gergely, Mechanics of Bond and Slip of Deformed Bars in Concrete, ACI Journal, Proceeding, V.64(11) (1976) 711-721

The same occurrence was also observed by [14], where the materials investigated seems to be aggregating closer to each other until it has reach the optimum stability.
Journal of Molecular Modeling, 22 (2016), 1-10 [9] Areerat, S., Funami.
Polymer Engineering and Science. 44(10), 1915-1924
Chinese Journal of Chemistry. 30, 115-120 [12] Sharudin, R.W., Ohshima, M. 2011.
Soft Materials, 10, 257-284 [15] Hansen, C.M. 2005.