Calcium Phosphate Based Bioceramics for Bone Tissue Engineering

Review from Ringgold Inc., ProtoView: The authors (both of the A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences) provide an overview of recent developments made in the field of calcium phosphate ceramic scaffolds for bone tissue engineering that emphasizes their own obtained results. After introducing the general concept of bone tissue engineering, they describe the structure of calcium orthophosphates and isomorphous substitutions; present synthesis and sintering methods, including their own synthesis of calcium phosphate nanoparticles and their investigation of thermal stability of substituted phosphates; describe calcium phosphate based granules, ceramics, composites, and cements, along with their results on the technology of porous ceramics, polymer-impregnated composites, and other materials; and present the results of a microstructural investigation of scaffolds and ex vivo tissue engineered bones by three dimensional techniques such as X-ray computer microtomography in reference to the kinetics of bone growth and the properties of engineered bone.