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Preparation and Research of Oil in Water Microemulsion

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Abstract:

A series of oil in water (O/W) microemulsions were prepared through drop by drop method at constant temperature, taking Span80/Tween80 as a composite emulsifying system and Macol-52 as oil phase. Effects of the mass ratio of composite emulsifying system and oil/emulsifier ratio on the particle size were studied. Finally, the best technological conditions were selected and the stability of the microemulsion was also researched. Results showed that the most suitable Span80/Tween80 mass ratio was 1:1 and the oil/emulsifier ratio is 1:1. Under this condition, the mean particle size of the o/w microemulsion was 71.1 nm and the polydispersity index was 0.151. Moreover, the microemulsion maintain a bright and uniform stable system after 20minutes’ centrifugation at the speed of 4000r/min and the particle size increased slightly.

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Periodical:

Materials Science Forum (Volume 1001)

Pages:

110-114

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.1001.110

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Online since:

July 2020

Authors:

Xiao Qi Chen, Meng Meng Zhou, Zheng Zheng Wang, Hai Jun Zhou, Shu Lan Yang, Xin Li, Xiong Wei Qu, Yan Tao Li*

Keywords:

Drug Carrier, Microemulsion, Oil in Water

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© 2020 Trans Tech Publications Ltd. All Rights Reserved

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