All-Trans Retinoic Acid (atRA) Release from atRA-Loaded Folate-Poly(Ethylene Glycol)/Polyethylenimine Nanoparticles for Folate-Mediated Tumor Targeting

Mi Kyong Yoo; You Kyoung Kim; Hwan Jeong Jeong; Hee Seung Bom; Chong Su Cho

doi:10.4028/www.scientific.net/KEM.342-343.509

Paper Titles

Hydrophobically Modified Amphiphilic Cylodextrins as Novel Carriers for Controlled Delivery of Water-Soluble Drugs
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Fabrication of Bio-Composite Drug Delivery System Using Rapid Prototyping Technology
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Supercritical Carbon Dioxide Assisted Impregnation of Molsidomine into Poly(_DL-Lactide-co-Glycolide) for Sustained Release Applications
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Release Profile of a Model Protein Drug Depending on the Stability of Microspheres Based on Polyelectrolyte Complex
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All-Trans Retinoic Acid (atRA) Release from atRA-Loaded Folate-Poly(Ethylene Glycol)/Polyethylenimine Nanoparticles for Folate-Mediated Tumor Targeting
p.509

The Double-Layered Microsphere: Encapsulation of Water-Soluble Protein with PLGA
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Controlled Angiogenic Factor Release from Alginate Gels
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Synthesis and Characterization of Polyethylenimine-Graft-Poly(L-Lactide-Co-Glycolide) Block Copolymers for Gene Delivery
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A Novel Degradation Controlled Hyaluronic Acid Derivatives
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All-Trans Retinoic Acid (atRA) Release from atRA-Loaded Folate-Poly(Ethylene Glycol)/Polyethylenimine Nanoparticles for Folate-Mediated Tumor Targeting

Abstract:

To improve the specific accumulation in tumor sites and aqueous solubility of atRA, the core-shell type of folate-PEG-g-PEI/atRA nanoparticles were prepared by complexation between cationic PEI segments in the copolymers and anionic charged atRA, and then characterized by 1HNMR, ELS, XRD, and TEM. In vitro atRA release from the nanoparticles was investigated as a function of drug content in sink condition. Cytotocicity of atRA against HepG2, KB cell lines were also evaluated by MTT assay. The lower the drug content, the faster atRA release. atRA incorporated in folate-PEG-g-PEI/atRA nanoparticles showed much higher cytotoxic effect compared with atRA itself.