Investigation on a Novel Sensing Technology for the Detection of Blood Coagulation Based on Liquid Resonance Characteristics

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Abstract:

Based on the liquid resonance principle, a novel sensing technology for detecting the blood coagulation was proposed. The course of blood coagulation can alter its inherent properties, such as viscosity and density. As a result, liquid resonance frequency of blood will change with the blood agglomeration. A gold-plated Interdigital Electrode (IDE) was fabricated and a detection system was designed for the acquisition of the frequency. The activated partial thromboplastin time (APTT) was measured using the IDE and the detection system. For four volunteers, the activated partial thromboplastin time measured is 22-37 seconds, which are consistent with the reference value 22-38 seconds. The results indicated that the liquid resonance frequency can characterize the course of blood coagulation.

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253-256

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December 2011

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[1] YU Kui, LIN Guoqing, QU Zhe et al. The state of the art of the blood coagulation analyzers, Information of Medical Equipment. 12 (2001) 40-41.

Google Scholar

[2] ZHAO Meng, FU Wei-ling, CHEN Ming et al.Exponential decay regularity of frequency and endpoint determination by maximalcurvature in piezoelectric coagulation, Acta Academiae Medicinae Militaris Tertiae. 28 (2006) 311-314.

Google Scholar

[3] Cheng T J, Chang H C, Lin T M.A piezoelectric quartz crystal sensor for the determination of coagulation time in plasma and whole blood, Biosensors Bioelectronics. 13 (1998) 147-156.

DOI: 10.1016/s0956-5663(97)00111-5

Google Scholar

[4] Ganter M T, H ofer C K. Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices, Anesth Analg. 106(5) (2008) 1366-1375.

DOI: 10.1213/ane.0b013e318168b367

Google Scholar

[5] Dai Y , Lee A , Critchley L A , et a1. Does thromboelastography predict postoperative thromboem bolic events? A systematic review of the literature, Anesth Analg. 108(3) (2009) 734-742.

DOI: 10.1213/ane.0b013e31818f8907

Google Scholar

[6] Kalina U , StOhr H A , Bickhard H , et a1. Rotational thromboelastography for monitoring of fibrinogen concentrate therapy in fibrinogen deficiency. Blood Coagul Fibrinolysis. 19(8) (2008) 777-783.

DOI: 10.1097/mbc.0b013e32830ef90c

Google Scholar