Today, a wide variety of methods to deal with uncertainty in load-carrying system exists. Thereby, uncertainty may result from not or only partially determined process properties. The present article proposes a classification of methods to control uncertainty in load-carrying systems from different disciplines within mechanical engineering. Therefore, several methods were collected, analysed and systematically classified concerning their characteristic into the proposed classification. First, the classification differs between degrees of uncertainty according to the model of uncertainty developed in the Collaborative Research Centre CRC 805. Second, the classification differs between the aim of the respective method to descriptive methods, evaluative methods or methods to design a system considering uncertainty. The classification should allow choosing appropriate methods during product and process development and thus to control uncertainty in a systematic and holistic approach.